ReviewJournal of assisted reproduction and genetics2026
The role of mTOR signaling in regulating the quality of mammalian oocytes.
Review in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundmTOR (mammalian target of rapamycin) is a central sensor of cellular nutrient and energy status. It regulates key biological processes, including metabolism, protein synthesis, and autophagy. Increasing evidence shows that mTOR signaling plays an important role in maintaining oocyte quality.
objectiveThis review aims to provide a systematic overview of how mTOR signaling regulates oocyte quality in mammals. CONTENT: We summarize current knowledge on the role of mTOR in key cellular processes related to oocyte competence. These processes include metabolic regulation, translational control, autophagy, and mitochondrial function. We also discuss evidence from experimental and clinical studies. These studies link dysregulated mTOR activity to impaired oocyte maturation and reduced fertility. KEY
findingsCurrent evidence shows that precise control of mTOR activity is essential for maintaining oocyte developmental potential. In contrast, the dysregulation of mTOR impairs oocyte quality and negatively affects reproductive outcomes.
conclusionA better understanding of mTOR-related regulatory mechanisms may help identify new therapeutic strategies. These strategies may improve oocyte quality and female fertility.
Indexed as
Identifiers
41949718What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.