Evidence map›Paper›PMID 41949796›Full record

SynthesisObesity surgery2026

Efficacy and Safety of Tranexamic Acid Use in Bariatric Surgery: An Updated Systematic Review and Meta-Analysis.

Lily J Park, Hannah Polley, Meredith Poole, Karanbir Brar, Tyler McKechnie, Rahima Nenshi, Flavia K Borges, Sandra Ofori, Maura Marcucci, David Conen and 5 more

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lily J ParkDepartment of Surgery, Division of General Surgery, McMaster University, Hamilton, Canada.
Hannah PolleySchool of Medicine, University of Limerick, Limerick, Ireland.
Meredith PooleDepartment of Surgery, Division of General Surgery, McMaster University, Hamilton, Canada.
Karanbir BrarDepartment of Surgery, Division of General Surgery, University of Toronto, Toronto, Canada.
Tyler McKechnieDepartment of Surgery, Division of General Surgery, McMaster University, Hamilton, Canada.
Rahima NenshiDepartment of Surgery, Division of General Surgery, McMaster University, Hamilton, Canada.
Flavia K BorgesPopulation Health Research Institute, Hamilton, Canada.
Sandra OforiPopulation Health Research Institute, Hamilton, Canada.
Maura MarcucciPopulation Health Research Institute, Hamilton, Canada.
David ConenPopulation Health Research Institute, Hamilton, Canada.
Yung LeeDigestive Disease Institute, Cleveland Clinic, Cleveland, United States.
Mehran AnvariDepartment of Surgery, Division of General Surgery, McMaster University, Hamilton, Canada.
Cagla EskiciogluDepartment of Surgery, Division of General Surgery, McMaster University, Hamilton, Canada.
Dennis HongDepartment of Surgery, Division of General Surgery, McMaster University, Hamilton, Canada.
P J DevereauxPopulation Health Research Institute, Hamilton, Canada. pj.devereaux@phri.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravenous tranexamic acid (TXA) is increasingly used to reduce perioperative bleeding. Its safety in bariatric surgery, a population with chronic inflammation and hypercoagulability, remains unclear. Following PRISMA guidelines, 11 comparative studies (five RCTs, four retrospective cohorts, two prospective cohorts; n = 1,959) were analyzed. TXA significantly reduced transfusion risk (RR 0.29, 95%CI 0.11–0.80), bleeding events (RR 0.46, 95%CI 0.32–0.67), postoperative hemoglobin reduction (MD 0.24 g/dL, 95%CI 0.04–0.44), length of stay, and operative time. Intraoperative blood loss was unchanged. RCT-only analyses showed consistent reductions in bleeding and hemoglobin drop. No deep venous thromboembolism events were reported. Overall, TXA may reduce bleeding-related outcomes in bariatric surgery without an observed thromboembolic signal, though low event rates limit certainty, and further randomized trials are needed. Word count: 120/125.

Indexed as

Antifibrinolytic AgentsBariatric SurgeryBlood Loss, SurgicalObesity, MorbidPostoperative HemorrhageTranexamic AcidHumansLength of StayTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidBariatric surgeryHemostasisPerioperative careProphylaxisTranexamic acid

Identifiers

PMID41949796

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.