ArticleJournal of clinical hypertension (Greenwich, Conn.)2026
Association Between Obesity Status and Hypertension Phenotypes: Are Inflammatory Indicators the Missing Link? Evidence From a Large Population Study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Phytochemicals and Irisin as Multi-Target Regulators of Adipose Tissue Browning and Metabolic Reprogramming: Synergies with GLP-1 Pathways.Antioxidants (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
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Abstract
Hypertension exhibits variability in diagnosis and treatment across phenotypes. Obesity and metabolic disorders are key risk factors, interacting with inflammatory states. This study explores their associations with hypertension phenotypes and the mediating role of inflammation. This study analyzed 17 158 participants from NHANES (2007-2018). Hypertension phenotypes were diagnosed per guidelines. Associations were evaluated using weighted generalized linear models, with the receiver operating characteristic(ROC) curves identifying optimal obesity indices. Stratified analyses were conducted by gender, lifestyle, and diet. Mediation analysis assessed inflammation's role. Among six obesity indicators, Weight-Waist Index (WWI) was better for Isolated Systolic Hypertension (ISH) (area under curve[AUC]:0.64, 95%confidence interval[CI]:0.62-0.67), Waist Circumference (WC) was better for Isolated Diastolic Hypertension (IDH) (AUC:0.68, 95%CI:0.67-0.69). High obesity indicators (WC for IDH, WWI for ISH and WC for SDH) without metabolic disorders linked to IDH (odds ratio[OR] 3.02, 95% CI 1.57-5.82), not ISH or Systolic-Diastolic Hypertension (SDH) (p > 0.05). High obesity indicators (WC for IDH, WWI for ISH and WC for SDH) with metabolic disorders associated with all phenotypes (IDH: OR 3.62, 95% CI 2.19-5.97; ISH: OR 1.76, 95% CI 1.09-2.84; SDH: OR 2.04, 95% CI 1.25-3.34). Inflammation mediated partially: 6.44% via RBC in IDH (non-obesity metabolic disorders, P < 0.001), 18.4% via Monocyte in ISH (obesity without metabolic disorders, P < 0.05). Stratified analyses showed phenotype-specific differences: IDH nonsignificant, ISH by smoking, SDH by age. High WC without metabolic disorders is linked to IDH, while metabolically disordered obesity correlates with all phenotypes. These effects are mediated by distinct variables, aiding phenotype-specific diagnosis and treatment.
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