ArticlePloS one2026
White matter microstructure disruption associated with PET and cognitive impairment in Alzheimer's disease.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is associated with regional brain atrophy as well as elevated positron emission tomography (PET) markers of amyloid-beta (e.g., [¹⁸F]florbetapir (FBP)) and tau protein (e.g., [¹⁸F]flortaucipir (FTP). White matter microstructures have also been shown to be disrupted in AD, but there is limited understanding of their specific associations with FBP, FTP, and cognitive impairment. Herein, we used both voxel-based and fixel-based analyses of diffusion tensor imaging (DTI) to characterize microstructural white matter changes associated with PET and cognitive changes in AD. A retrospective study was performed using the data from 381 ADNI-3 participants (F:M = 200:181). FBP and FTP results were correlated with DTI metrics, including the apparent fiber density (AFD), complexity (CX), functional anisotropy (FA), fixel number (FN), and mean diffusivity (MD). Linear regression analysis was performed, adjusted for age, sex, education, and cognitive impairment. Greatest negative correlations were observed between FN and FBP standardized uptake value ratio (SUVR) in 15 out of 18 white matter tracts examined (beta coefficients of -0.3991 to -0.2877). No significant correlation was observed between DTI measures and FTP SUVR, independently. However, combined PET positivity (FBP + /FTP+) generally showed the greatest reductions in CX, FN, and FA of various tracts, compared to single PET-positive or PET-negative groups. Widespread changes in FA were positively associated with cognitive impairment, with stronger associations seen with the Montreal Cognitive Assessment (MoCA) than the Mini-Mental State Examination (MMSE). Only females showed significant correlations between MD and FBP/FTP levels and showed more widespread correlations between FA and MD changes and cognitive impairment. Taken together, these findings suggest specific patterns of white matter microstructure disruption in AD with underlying sex differences and support their potential role as early biomarkers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.