Evidence map›Paper›PMID 41950321›Full record

ArticleScience advances2026

CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4

Rui Hirasawa, Chiaki Iwamura, Masahiro Kiuchi, Takahisa Hishiya, Atsushi Sasaki, Kohei Kakinuma, Kanae Ohishi, Akane Kurosugi, Masahiro Nemoto, Kota Kokubo and 11 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Rui HirasawaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-0799-3581
Chiaki IwamuraDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0003-3537-8073
Masahiro KiuchiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-0227-4502
Takahisa HishiyaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-7049-8615
Atsushi SasakiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-6127-7714
Kohei KakinumaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kanae OhishiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0009-0003-6194-2632
Akane KurosugiDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masahiro NemotoDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-8413-2136
Kota KokuboDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-6896-1981
Takuto HiramotoDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0009-0000-9185-0331
Tomohisa IinumaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-9940-5520
Syuji YonekuraDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-1408-9072
Atsushi OnoderaInstitute for Advanced Academic Research, Chiba University, Chiba, Japan.ORCID 0000-0002-3715-9408
Motoko Y KimuraSynergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, Chiba, Japan.ORCID 0000-0002-5607-5066
Shinichiro MotohashiDepartment of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-9332-3129
Damon J TumesCentre for Cancer Biology, The University of South Australia and SA Pathology, Adelaide, Australia.ORCID 0000-0001-5709-857X
Toyoyuki HanazawaDepartment of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-9721-5662
Toshinori NakayamaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Seiji OhtoriDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0001-5738-6184
Kiyoshi HiraharaDepartment of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID 0000-0002-9128-9449

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-resident memory T cells (T

Indexed as

Antigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesEpigenesis, GeneticGenomic ImprintingImmunologic MemoryLectins, C-TypeMemory T CellsAnimalsCD69 AntigensHumansMiceSphingosine-1-Phosphate ReceptorsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensLectins, C-TypeSphingosine-1-Phosphate Receptors

Identifiers

PMID41950321
PMCPMC13060599

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.