Evidence map›Paper›PMID 41950328›Full record

ArticleScience advances2026

Vasculogenic tissue nanotransfection accelerates functional recovery after peripheral nerve injury.

Ana I Salazar-Puerta, Sara Kheirkhah, Jonathan P Stranan, Hallie Harris, Nada Khattab, Megumi Fukuda, Grant Barringer, Carlos A Vasquez-Martinez, Samuel Cortes, Neil Ott and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ana I Salazar-PuertaDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-4954-6226
Sara KheirkhahDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0009-0003-3765-3953
Jonathan P StrananDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0009-0002-5349-0333
Hallie HarrisDepartment of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH, USA.ORCID 0000-0003-4819-0432
Nada KhattabDepartment of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH, USA.
Megumi FukudaDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Grant BarringerDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Carlos A Vasquez-MartinezDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Samuel CortesBiomedical Science, The Ohio State University, Columbus, OH, USA.
Neil OttDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
William R LawrenceDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-8639-3420
Devleena DasDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-9789-2161
Jordan T MooreDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-6391-8471
Tiam M SaffariDepartment of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH, USA.
Juan D Salazar-GilDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Diego Alzate-CorreaDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0001-5750-0207
Junyan YuDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0009-0003-8017-0092
Kavya DathathreyaDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-1994-8366
Natalia Higuita-CastroDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-3297-6281
Tatiana Z Cuellar-GaviriaDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-0822-4784
W David ArnoldDepartment of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA.ORCID 0000-0001-9889-7036
Amy M MooreDepartment of Plastic and Reconstructive Surgery, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-4951-1325
Daniel Gallego PerezDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-6263-3191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injuries (PNIs) remain a major clinical challenge, often leaving patients with lifelong sensory, motor, and functional impairments despite surgical repair. While gene and cell therapies hold promise, their translation has been hampered by the lack of safe, efficient, and targeted delivery strategies. Here, we introduce vasculogenic tissue nanotransfection (TNT) as a nonviral, reprogramming-based therapeutic platform to enhance nerve regeneration to augment surgical reconstruction. This one-time, millisecond-scale intervention reprograms resident cells in situ toward a vasculogenic phenotype, fostering neovascularization and vascular remodeling to support axonal regeneration. Through integrated in vitro screening and in vivo validation, we identified an optimized formulation of vasculogenic genes (

Indexed as

Neovascularization, PhysiologicNerve RegenerationPeripheral Nerve InjuriesRecovery of FunctionAnimalsAxonsDisease Models, AnimalHumansMice

Identifiers

PMID41950328
PMCPMC13060591

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.