ArticleVirchows Archiv : an international journal of pathology2026
Mucosal melanoma: clinicopathological, molecular and prognostic features in a retrospective cohort.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
Mucosal melanoma represents a rare, aggressive malignancy with limited therapeutic options and sparse data on prognostic markers. Here, we assess histopathologic and molecular parameters influencing survival to identify features applicable in routine diagnostics. A retrospective single-centre clinicopathological study of 51 patients diagnosed with mucosal melanoma (genitourinary, head and neck and gastrointestinal) between 2016 and 2024 was performed. Histopathological parameters, including tumour-infiltrating lymphocytes, were assessed by pathologists with expertise on melanocytic lesions. Molecular data derived from previously performed next-generation sequencing panels targeting common oncogenic drivers were retrieved from pathology records. Molecular and histopathological findings were correlated with clinical data and survival outcomes. The findings highlight the prognostic relevance of proliferative activity and residual in situ disease. Disease-free survival was significantly reduced in patients with metastatic (M1) status, ulceration, ≥10 mitoses/mm
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