Evidence map›Paper›PMID 41953019›Full record

ArticleFrontiers in immunology2026

CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response.

Ruihua Xin, Wenshu Zou, Zhengying Qiu, Lina Huang, Xiaohan Jing, Qilin Huang, Zixiang Zhu, Jianxi Li, Mutien-Marie Garigliany

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruihua Xin *Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Technology Innovation Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Wenshu Zou *Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, China.
Zhengying QiuKey Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Technology Innovation Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Lina HuangKey Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Technology Innovation Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Xiaohan JingKey Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Technology Innovation Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Qilin HuangKey Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Technology Innovation Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zixiang ZhuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Jianxi LiKey Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Technology Innovation Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Mutien-Marie GariglianyFundamental and Applied Research for Animals & Health (FARAH), Institute of Epidemics (INDEEP), Laboratory of Pathology, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ubiquitination is a pivotal post-translational mechanism regulating antiviral innate immunity. TRIM28, a member of the transcription intermediary factor 1 (TIF1) subfamily of the TRIM protein family, has been implicated in the modulation of retinoic acid-inducible gene I (RIG-I) signaling. However, the molecular basis and Methods: TRIM28 overexpression and knockdown systems were used to evaluate type I interferon (IFN) responses and RNA virus replication Results: TRIM28 knockdown enhanced type I IFN responses and inhibited RNA virus replication Conclusion: TRIM28 functions as a negative regulator of RIG-I-mediated antiviral signaling by promoting K48-linked ubiquitination of MAVS. These findings define the TRIM28-MAVS axis as a regulatory checkpoint in innate antiviral immunity and suggest its potential as a target for antiviral intervention.

Indexed as

Adaptor Proteins, Signal TransducingDEAD Box Protein 58KaryopherinsReceptors, Cytoplasmic and NuclearTripartite Motif-Containing Protein 28Active Transport, Cell NucleusAnimalsCell NucleusExportin 1 ProteinHEK293 CellsHumansImmunity, InnateInterferon Type IMiceSendai virusSignal TransductionAdaptor Proteins, Signal TransducingDEAD Box Protein 58Exportin 1 ProteinInterferon Type IKaryopherinsReceptors, Cytoplasmic and NuclearTripartite Motif-Containing Protein 28MAVSnucleocytoplasmic traffickingRIG-I signalingRNA virus replicationTRIM28ubiquitination

Identifiers

PMID41953019
PMCPMC13053320

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.