Evidence map›Paper›PMID 41953144›Full record

ArticleBioactive materials2026

Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling.

Jiaqian Zheng, Junhua Ke, Shiyu Wu, Yang Lan, Zhouhua Zhong, Siyuan Yang, Naru Zhao, Zhen Wang, Muyuan Chai, Xuetao Shi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiaqian ZhengSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Junhua KeSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Shiyu WuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Yang LanSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Zhouhua ZhongSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Siyuan YangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Naru ZhaoSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Zhen WangNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR China.
Muyuan ChaiSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Xuetao ShiSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.
Yingjun WangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Critical segmental bone defects (CSBDs) heal poorly in the aging microenvironment, leading to high complication rates. This study developed a novel periosteum with epigenetic reprogramming capability to address this challenge. The material combines a three-layer structure with bone fracture-derived extracellular vesicles (BFVs) from juvenile mice. It demonstrated stable BFV release over 14 days and favorable tensile properties (modulus ∼0.22 MPa, elongation ∼200%).

Indexed as

AgingCritical segmental bone defectsEpigenetic reprogrammingExtracellular vesiclesPeriosteum

Identifiers

PMID41953144
PMCPMC13054291

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.