Observational studyFrontiers in endocrinology2026
Real-world glycemic control, exploratory cardiorenal indicators, and safety of polyethylene glycol loxenatide versus semaglutide in type 2 diabetes patients: a Chinese two-center retrospective cohort study.
Observational study in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Objective: To compare the real-world efficacy and safety of high dose once-weekly glucagon-like peptide-1 receptor agonists polyethylene glycol loxenatide (PEG-Loxe) and subcutaneous (s.c.) semaglutide in patients with suboptimally controlled type 2 diabetes mellitus (T2DM). Methods: We conducted a retrospective cohort China two-center study. Patients newly initiated on once-weekly PEG-Loxe 200 μg or s.c. semaglutide 1.0 mg between January 2021 and October 2022 were matched 1:1 using propensity score matching. The primary endpoint was change from baseline in glycated hemoglobin (HbA1c) at 24 months. Secondary endpoints included changes in HbA1c, body weight (BW), body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), and estimated glomerular filtration rate (eGFR) from baseline to 3, 6, 12, and 24 months. Records of adverse drug reactions were collected and extracted from the institutional medical record system. Results: A total of 510 matched patient pairs demonstrated balanced baseline characteristics. No statistically significant between-group difference was observed in HbA1c changes from baseline across all follow-up assessments ( Conclusions: In real-world clinical practice, at the same high dose, PEG-Loxe provided equivalent glycemic control to s.c. semaglutide with a potential lower incidence of gastrointestinal side effects. Conversely, semaglutide offered more substantial improvement of cardiorenal parameters. These findings highlight the clinical utility of both agents in personalized T2DM management.
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