Evidence mapPaperPMID 41953857Full record

ArticleExploration of digestive diseases2026

Understanding Liver and Digestive Diseases: A Paved Road to Improve Diagnosis, Management, and Treatment.

Ina Bergheim, Jean Francois Cadranel, Jian Guo Chen, Weng Xin Ding, Robert Eferl, Carmen Garcia-Ruiz, Hartmut Jaeschke, Firouzeh Kazerouni, Amedeo Lonardo, Derek A Mann and 8 more

Abstract read
In one paragraph

Article in Exploration of digestive diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ina BergheimUniversity of Vienna, Department of Nutritional Sciences, Molecular Nutritional Science, A-1090 Vienna, Austria.ORCID 0000-0002-3356-4115
Jean Francois CadranelDepartment of Liver and Digestive Diseases, Groupe Hospitalier Public du Sud de l'Oise, 60100 Creil, France.ORCID 0000-0002-8442-4526
Jian Guo ChenQidong Liver Cancer Institute, Qidong, Jiangsu, 226200, P. R. China.ORCID 0000-0003-4102-8934
Weng Xin DingDepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID 0000-0002-3167-5073
Robert EferlCenter for Cancer Research, Medical University of Vienna, A-1090 Vienna, Austria.ORCID 0000-0002-6074-7144
Carmen Garcia-RuizDepartment of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), CSIC, 08036 Barcelona, Spain.ORCID 0000-0002-2652-6102
Hartmut JaeschkeDepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID 0000-0002-8695-6980
Firouzeh KazerouniDepartment of Medical Imaging, Groupe Hospitalier Public du Sud de l'Oise, 60100 Creil, France.
Amedeo LonardoDepartment of Internal Medicine, Azienda Ospedaliero-Universitaria di Modena, 41100 Modena, Italy.ORCID 0000-0001-9886-0698
Derek A MannBiosciences Institute, University of Newcastle, Newcastle, NE24HH, United Kingdom.ORCID 0000-0003-0950-243X
Nahum Mendez-SanchezLiver Research Unit, Medica Sur Clinic and Foundation, Mexico City 14050, Mexico.ORCID 0000-0001-5257-8048
Camelia MokhtariDepartement of Laboratory, Groupe Hospitalier Public du Sud de l'Oise, 60100 Creil, France.
Han MoshageDept. Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Hanzeplein 1; 9713 GZ Groningen, The Netherland.ORCID 0000-0002-4764-0246
Chiara RaggiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-2473-3535
Pavel StrnadUniversity Hospital Aachen. Head, Research Laboratory in Translational Gastroenterology, 52074 Aachen, Germany.ORCID 0000-0002-7122-6379
Oren TiroshInstitute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.ORCID 0000-0001-5407-0440
Honoré Tegwende ZougmoreDepartment of Liver and Digestive Diseases, Groupe Hospitalier Public du Sud de l'Oise, 60100 Creil, France.
Jose C Fernandez-ChecaDepartment of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), CSIC, 08036 Barcelona, Spain.ORCID 0000-0003-3422-2990

Funding

Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2025 to 2025
$2.3M
NCI NIH HHS P01 CA281819
6 · The paper itself

Abstract

Digestive diseases comprise a diverse range of illnesses, which are prevalent worldwide and represent an important health issue. This is particularly relevant for the impact of metabolic-associated steatotic liver disease (MASLD) due to its close association with the obesity pandemic, contributing to the escalation of MASLD as the most common form of chronic liver disease, and the main cause of liver cancer. Not only MASLD reflects the deterioration of liver health, but also has far-reaching consequences for the development of extrahepatic digestive diseases. Along with progression of liver and digestive diseases to liver, colorectal and pancreatic cancer, the onset of inflammatory diseases of the digestive tract, drug-induced liver injury, and cholestasis, the overall impact of these hepatic and digestive diseases is expected to rise in the future and hence merits the attention of clinical and translational research to increase our understanding of the pathogenic mechanisms underlying these disorders in order to improve the diagnosis, management and treatment. With this goal in mind, the current collaborative review gathers experts in a wide range of liver and digestive diseases to provide an up-to-date overview of the mechanisms of disease and identify novel strategies for the improvement of these important health issues.

Indexed as

cholestasiscolorectal cancerdrug induced liver injuryinflammatory bowel diseaseLiver cancer

Identifiers

PMID41953857
PMCPMC13056384

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.