SynthesisEuropean journal of public health2026
Maternal and child nutrition insecurity, microbiome, and early neurodevelopment: an intricate interplay. Results from a systematic review.
Synthesis in European journal of public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Emerging research suggests nutrition insecurity influences microbiome composition, which in turn affects early neurodevelopment through the gut-brain axis. This systematic review aimed to evaluate evidence on these relationships. A comprehensive search of the scientific literature was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies investigating the links between nutrition insecurity in mothers and children, microbiome, and early neurodevelopment were included. Data on maternal characteristics, microbiota composition, neurodevelopmental outcomes, and nutritional status were extracted from eligible studies. The review included 11 studies, primarily cohort studies, conducted in various countries. According to the study findings, gut maternal and infant microbiota composition in early life appear to be closely connected to early neurodevelopment both in terms of cognitive/motor skills and temperament. Nutrition insecurity has a significant influence in shaping these outcomes as it can alter microbiota balance and contribute to gut dysbiosis and delayed neurodevelopmental milestones. Breastfeeding emerges as a crucial factor in modulating the infant microbiome and supporting neurodevelopment. Also, other factors such as pre-pregnancy overweight/obesity and environment seem to influence offspring gut colonization and neurodevelopmental outcomes. This systematic review highlights the intricate interplay between maternal and child nutrition insecurity, microbiota, and early neurodevelopment. These findings underscore the critical need for targeted interventions addressing maternal and child nutrition to mitigate the adverse effects of nutrition insecurity and support optimal early-life neurodevelopment. Future research should focus on longitudinal studies to explore the causal pathways and to develop nutrition-based strategies to prioritize microbiome health in vulnerable and at-risk populations.
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