Evidence map›Paper›PMID 41955115›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation.

Liangliang Wang, Yiru Wang, Yaqi Miao, Yuan Song, Jialiang Zhou, Yuanxiang Zhu, Ying Cheng, Wenxin Zhang, Qinmiao Sun, Fan Lai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liangliang Wang *Institute of Biomedical Research, Yunnan University, Kunming 650500, China.ORCID 0000-0003-0017-7132
Yiru Wang *Institute of Biomedical Research, Yunnan University, Kunming 650500, China.
Yaqi Miao *State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Yuan SongState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Jialiang ZhouInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.
Yuanxiang ZhuInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.ORCID 0000-0002-9140-5622
Ying ChengInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.ORCID 0000-0002-4233-5330
Wenxin ZhangInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.ORCID 0009-0002-5886-3258
Qinmiao SunState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0001-8091-1653
Fan LaiSouthwest United Graduate School, Kunming 650500, China.ORCID 0000-0002-0568-2616
Guoqiang ZhangInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.ORCID 0000-0002-0423-5769
Dahua ChenInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.ORCID 0000-0002-2122-9141

Funding

Excellence Research Group Program of NFSC 32588201National Key R&D Program of China 2021YFA0805800National Key R&D Program of China 2023YFA1801900Yunnan Provincial Science and Technology Department () 202105AB160002Yunnan Provincial Science and Technology Department () 202302AO370011
6 · The paper itself

Abstract

Zygotic genome activation (ZGA) marks the first transcriptional milestone and establishes embryonic totipotency. Although pioneer factors have been reported to initiate this process, how chromatin is primed for the totipotent state, allowing the binding of pioneer factors for successful ZGA, remains unclear. Here, we identify IntS11, the catalytic subunit of the Integrator complex, as a totipotent determinant of embryonic chromatin governing ZGA in

Indexed as

Drosophila melanogasterDrosophila ProteinsTranscription Initiation, GeneticZygoteAnimalsChromatinFemaleGene Expression Regulation, DevelopmentalNuclear ProteinsRNA Polymerase IITranscription, GeneticChromatinDrosophila ProteinsNuclear ProteinsRNA Polymerase IIzld protein, DrosophilaDrosophilaearly embryoIntegrator complexzygotic genome activation

Identifiers

PMID41955115
PMCPMC13079923

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.