Evidence map›Paper›PMID 41955967›Full record

ReviewNeoplasia (New York, N.Y.)2026

Targeting tumor dormancy: the next frontier in gastrointestinal stromal tumor therapy.

Sihan Wu, Hao Liu, Yuhan Yin, Jiehan Li, Zhen Zhang, Wei Li, Yang Fu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neoplasia (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sihan WuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Hao LiuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yuhan YinDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Jiehan LiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zhen ZhangDepartment of Abdominal and Pelvic Tumor Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
Wei LiDepartment of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China. Electronic address: zlyylw3028@zzu.edu.cn.
Yang FuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Electronic address: fuyang@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal stromal tumors (GISTs), the most common mesenchymal neoplasms of the digestive tract, are primarily driven by mutations in KIT/PDGFRA. The remarkable success of tyrosine kinase inhibitors such as imatinib (IM) in treating GIST has established them as a paradigm of precision medicine in modern oncology. However, acquired resistance to IM remains a major cause of poor prognosis in GIST patients. Exploring novel mechanisms of IM resistance is critically important for improving outcomes. Tumor dormancy and cancer stem cell (CSC) models, observed across multiple malignancies, are closely linked to therapy resistance, tumor recurrence, and metastasis. Emerging evidence suggests that analogous non-genetic persistence states also exist in GIST, including dormant cells and KIT

Indexed as

Gastrointestinal NeoplasmsGastrointestinal Stromal TumorsAnimalsAntineoplastic AgentsDrug Resistance, NeoplasmHumansMolecular Targeted TherapyNeoplastic Stem CellsProtein Kinase InhibitorsProto-Oncogene Proteins c-kitAntineoplastic AgentsProtein Kinase InhibitorsProto-Oncogene Proteins c-kitCancer stem cellDrug resistanceGastrointestinal stromal tumorTumor dormancy

Identifiers

PMID41955967
PMCPMC13091209

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.