Understanding thyroid hormone receptor function in controlling developmental timing and rate in Xenopus: A journey from biochemistry and molecular biology to genetics.

Yun-Bo Shi

Abstract readReview

In one paragraph

Review in General and comparative endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Yun-Bo ShiSection on Molecular Morphogenesis, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD 20892, United States. Electronic address: Shi@helix.nih.gov.

Funding

MOLECULAR MECHANISM OF FROG METAMORPHOSISZ01HD001901 · CHILD HEALTH AND HUMAN DEVELOPMENT · 1995 to 2005

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Intramural NIH HHS Z01 HD001901Intramural NIH HHS Z01 HD008858

6 · The paper itself

Abstract

Anuran metamorphosis has long been used as a model to study thyroid hormone (T3) function during vertebrate development. The cloning of T3 receptor (TR) in the late 1980 s opened a door for using anuran metamorphosis to address some fundamental questions on T3 action in development that were difficult to ask or address in mammalian models. Here, I will review some of the studies ranging from biochemical and molecular investigations to more recent genetic studies that have not only uncovered novel and critical roles of TR in regulating adult organ development and larval tissue resorption/remodeling but also revealed in vivo mechanisms of T3 action. I will focus mainly on the work involving two highly related species, the allotetraploid Xenopus laevis and diploid Xenopus tropicalis, which offer many unique but complementary advantages for in vivo studies of TR function.

Indexed as

Receptors, Thyroid HormoneXenopusAnimalsMetamorphosis, BiologicalMolecular BiologyThyroid HormonesXenopus laevisReceptors, Thyroid HormoneThyroid HormonesAmphibian metamorphosisPostembryonic developmentThyroid hormone receptorTranscriptional activationTranscriptional repressionXenopuslaevisXenopustropicalis

Identifiers

PMID41956166

DOI10.1016/j.ygcen.2026.114927

PMCPMC13289794

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.