Evidence map›Paper›PMID 41956323›Full record

Trial reportThe American journal of clinical nutrition2026

Determining the half-life and turnover rate of EPA, n-3 docosapentaenoic acid, and DHA in humans using the natural abundance of carbon-13: a secondary analysis of a randomized clinical trial.

Amy Symington, Daiqing Wu, Chuck T Chen, Melissa Del Vecchio, Peter Zahradka, Carla Taylor, Harold M Aukema, Dehan Kong, Adam H Metherel, Richard P Bazinet

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amy SymingtonDepartment of Nutritional Sciences, University of Toronto, Ontario, Canada. Electronic address: amy.symington@mail.utoronto.ca.
Daiqing WuDepartment of Statistical Sciences, University of Toronto, ON, Canada.
Chuck T ChenDepartment of Nutritional Sciences, University of Toronto, Ontario, Canada.
Melissa Del VecchioDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada.
Peter ZahradkaCanadian Centre for Agri-Food Research in Health and Medicine, St Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.
Carla TaylorDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.
Harold M AukemaDepartment of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Canadian Centre for Agri-Food Research in Health and Medicine, St Boniface Albrechtsen Research Centre, Winnipeg, MB, Canada.
Dehan KongDepartment of Statistical Sciences, University of Toronto, ON, Canada.
Adam H MetherelDepartment of Nutritional Sciences, University of Toronto, Ontario, Canada.
Richard P BazinetDepartment of Nutritional Sciences, University of Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTools to measure omega-3 (n-3) polyunsaturated fatty acid (PUFA) half-lives and turnover deserve attention, as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) play vital roles in the body. Plants and marine life vary in fixed carbon-13 signatures (δ

objectivesTo determine the half-lives and turnover of n-3 PUFAs using δ

methodsDuring a 28-d randomized crossover study (6-wk wash-in phase/washout phase), 12 participants (aged 19-34 y) were supplemented with 4.2 g/d α-linolenic acid (ALA) (flax oil) or 4.3 g/d DHA, 1.0 g/d EPA, and 0.2 g/d docosapentaenoic acid (n-3 DPA) (fish oil). Blood was collected on days 0, 1, 3, 7, 14, and 28. Plasma n-3 PUFA δ

resultsδ

conclusionsThis is the first study to investigate n-3 PUFA half-lives and turnover in humans using GC-IRMS and the natural variance of

Indexed as

Carbon IsotopesDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, UnsaturatedAdultalpha-Linolenic AcidCross-Over StudiesDietary SupplementsFemaleHalf-LifeHumansMaleYoung Adultalpha-Linolenic AcidCarbon-13Carbon IsotopesDocosahexaenoic Acidsdocosapentaenoic acidEicosapentaenoic AcidFatty Acids, Unsaturatedbiomarkerscompound-specific isotope analysisDHAfatty acid metabolismhalf-lifeMSomega-3 PUFAsturnover rates

Identifiers

PMID41956323
PMCPMC13269626

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.