Evidence map›Paper›PMID 41957045›Full record

ArticleNPJ primary care respiratory medicine2026

Projecting the 20-year healthcare resource burden of asthma and COPD multimorbidity: insights from Singapore for integrated chronic respiratory care in South-East Asia.

Yah Ru Juang, Laura Huey Mien Lim, Sanjay H Chotirmall, Kelvin Bryan Tan, Mariko Siyue Koh, John A Abisheganaden, David B Price, Ming-Ju Tsai, Mei Fong Liew, Pei Yee Tiew and 2 more

Abstract read
In one paragraph

Article in NPJ primary care respiratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yah Ru Juang *Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Laura Huey Mien Lim *Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. hmienlim@yahoo.com.
Sanjay H ChotirmallLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Kelvin Bryan TanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Mariko Siyue KohDepartment of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore.
John A AbisheganadenLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
David B PriceObservational and Pragmatic Research Institute, Singapore, Singapore.
Ming-Ju TsaiDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Mei Fong LiewDivision of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore.
Pei Yee TiewLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Anthony Chau Ang YiiDepartment of Respiratory and Critical Care Medicine, Changi General Hospital, Singapore, Singapore.
Wenjia ChenSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma and chronic obstructive pulmonary disease (COPD) incur significant comorbidity and healthcare burden. However, their future economic burden remain unclear.

objectiveTo project 20-year (2024-2043) asthma and COPD multimorbidity costs in Singapore, illustrating broader Southeast Asian trends.

methodsPatients with asthma (all ages) or COPD (

resultsAsthma cases are projected to triple from 64,338 in 2019 to 192,409 by 2043 (95% confidence interval [CI]: 165,493-225,141), incurring $7.8 billion (95% CI: 4.4-17.1) from 2024-2043. Apart from asthma (16.4%), costs are driven by metabolic (20.0%), circulatory (14.3%), and other respiratory (9.2%) diseases, with children bearing the highest burden (girls: 39.9%; boys: 22.6%). COPD cases would grow from 8,988 in 2019 to 11,038 (95% CI: 8395-13,326) in 2043, incurring $2.4 billion (95% CI: 1.6-4.5) from 2024-2043. Apart from COPD (20.3%), metabolic (17.4%), circulatory (17.0%), and other respiratory diseases (9.8%) are the largest cost components, with elderly and adult males bearing the highest burdens (47.8% and 40.1%). In both cohorts, 20-year projected costs are dominated by outpatient (55%) and hospitalisation costs (30-40%).

conclusionThe 20-year multimorbidity costs of asthma and COPD are significant, especially in cardiometabolic comorbidities, underscoring the need for holistic, value-based care.

Indexed as

AsthmaHealth Care CostsMultimorbidityPulmonary Disease, Chronic ObstructiveAdultAgedAsia, SoutheasternCost of IllnessFemaleHospitalizationHumansMaleMiddle AgedSingapore

Identifiers

PMID41957045
PMCPMC13270152

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.