Evidence map›Paper›PMID 41957422›Full record

ArticleScientific reports2026

CD204 regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following intracerebral hemorrhage.

Wujie Shi, Xu Li, Jing Meng, Min Li, Hanhai Zeng, Jing Cai

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wujie ShiNeurosurgery, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xu LiNeurosurgery, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, 310000, China.
Jing MengNeurosurgerical Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310000, China.
Min LiNeurosurgerical Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310000, China.
Hanhai ZengNeurosurgery, The Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, 310000, China. 11918362@zju.edu.cn.
Jing CaiNeurosurgerical Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310000, China. 2505026@zju.edu.cn.

Funding

National Natural Science Foundation of China 82401514
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a main cause of death and disability worldwide. Microglial/macrophage activation and neuroinflammation are key events following ICH, but the molecular mechanisms of mediator regulatory function are not well understood. Cluster of differentiation 204 (CD204), a macrophage scavenger receptor, regulates multiple features of microglial/macrophage physiology. However, its function in regulating the innate immune response and microglial/macrophage M1/M2 polarization in ICH has not been addressed. In the current study, we aimed to investigate whether CD204 is involved in the regulation of M1/M2 microglial/macrophage polarization and neuroinflammation following ICH. The ICH mouse model was employed. CD204 siRNA was intracerebroventricularly administered, and tamibarotene was intraperitoneally administered for intervention. The neurobehavioral assessments, RT-PCR, Western blot, immunohistochemistry, Nissl staining, and ELISA were performed. CD204 is upregulated and regulates microglial/macrophage M1/M2 polarization and neuroinflammation in ICH. Mechanistically, inhibition of CD204 markedly decreases microglial/macrophage M2-like polarization while increases M1-like polarization, which exacerbates the brain injury after ICH. Tamibarotene exerts beneficial effects in ICH mice through CD204 activation. CD204 plays an important role in M1/M2-macrophage/microglial polarization, providing novel potential therapeutic targets for the regulation of immune and inflammatory disorders in ICH.

Indexed as

Cerebral HemorrhageMacrophagesMicrogliaNeuroinflammatory DiseasesScavenger Receptors, Class AAnimalsBenzoatesCell PolarityDisease Models, AnimalMacrophage ActivationMaleMiceMice, Inbred C57BLTetrahydronaphthalenesBenzoatesMsr1 protein, mouseScavenger Receptors, Class AtamibaroteneTetrahydronaphthalenesCD204ICHM1/M2 polarizationMicroglia/macrophageNeuroinflammation

Identifiers

PMID41957422
PMCPMC13201578

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.