Evidence map›Paper›PMID 41957858›Full record

ArticleChinese medicine2026

Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathway.

Lu Zhang, Jie Chen, Sauchu Yuen, Meiling Wu, Wenting Li, Shenyu Yan, Jiangang Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lu Zhang *School of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Jie Chen *School of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Sauchu YuenSchool of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Meiling WuSchool of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Wenting LiSchool of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Shenyu YanSchool of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Jiangang ShenSchool of Chinese Medicine, State Key Laboratory of Pharmaceutical Biotechnology, LKS Faculty of Medicine, The University of Hong Kong, 3 Sassoon Road, Pokfulam, Hong Kong SAR, China. shenjg@hku.hk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple Sclerosis (MS) is a neuroinflammatory disease affecting the central nervous system (CNS), for which effective therapeutic strategies remain limited. Ganoderma Lucidum (GL) is a nature healthy food supplement whose effects on MS remain unknown. Using an experimental autoimmune encephalomyelitis (EAE) mouse model, we tested the hypothesis that GL could mitigate MS by inhibiting microglial activation and promoting a shift toward an anti-inflammatory M2-like phenotype. We demonstrate that early preventive administration of GL significantly reduced disease severity, inflammatory infiltration, demyelination, and microglial activation and polarization by promoting M2-like polarization in the spinal cord of EAE mice. Furthermore, using in vitro cellular experiments, GL revealed antioxidant and anti-inflammatory effects by scavenging superoxide (O

Indexed as

Experimental autoimmune encephalomyelitisGanoderma lucidumMicroglia polarizationMultiple sclerosisNuclear factor-kappa BSignal transducer and activator of transcription 3

Identifiers

PMID41957858
PMCPMC13067805

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.