Evidence map›Paper›PMID 41957893›Full record

ArticleJournal of traumatic stress2026

Posttraumatic stress symptom reduction after gender-affirming medical interventions: A longitudinal study.

James Michael Brennan, Nadra E Lisha, Nguyen Khai Tran, Kelly Davis, Juno Obedin-Maliver, Mitchell R Lunn, Annesa Flentje

Abstract read
In one paragraph

Article in Journal of traumatic stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James Michael BrennanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7695-5028
Nadra E LishaDivision of Prevention Science, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Nguyen Khai TranThe PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, California, USA.
Kelly DavisSalem VA Health Care System, Salem, Virginia, USA.
Juno Obedin-MaliverThe PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, California, USA.
Mitchell R LunnThe PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, California, USA.
Annesa FlentjeThe PRIDE Study/PRIDEnet, Stanford University School of Medicine, Stanford, California, USA.

Funding

Patient-Centered Outcomes Research Trust Fund (PCOR Trust Fund) PPRN-1501-26848
6 · The paper itself

Abstract

Transgender and gender expansive (TGE) people experience high levels of posttraumatic stress disorder (PTSD). Gender-affirming medical interventions (GAMIs) may be helpful in reducing PTSD symptoms. This study examined whether GAMIs were associated with reduced PTSD symptom severity longitudinally and whether the association was mediated by gender minority stress (GMS) and depressive symptoms. TGE participants (N = 2,514) from a national cohort study were included if they attained at least one GAMI at one or more points during 2019-2022. Two longitudinal models were run, adjusted for time and baseline covariates: (a) an interrupted time series analysis (ITSA) examining changes in PTSD scores after receiving at least one GAMI (GAMI indicator) at each annual time point and (b) a mixed-effects longitudinal model examining the association between GAMI count and PTSD scores. Structural equation modeling tested whether latent GMS and depressive symptoms mediated these longitudinal associations. Unadjusted and minimally adjusted models demonstrated significant PTSD score reductions (a) immediately after the third GAMI indicator (ITSA model), B

Indexed as

Stress Disorders, Post-TraumaticTranssexualismAdultDepressionFemaleHumansLongitudinal StudiesMaleMiddle Aged

Identifiers

PMID41957893
PMCPMC13436498

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.