Evidence map›Paper›PMID 41958080›Full record

ReviewJournal of cellular and molecular medicine2026

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma.

Ana B Caniceiro, Sofia P Agostinho, Luiz F Piochi, Nícia Rosário-Ferreira, Irina S Moreira

Abstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana B CaniceiroCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Sofia P AgostinhoPURR.AI, Rua Pedro Nunes, IPN Incubadora, Ed C, Coimbra, Portugal.
Luiz F PiochiCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Nícia Rosário-FerreiraPURR.AI, Rua Pedro Nunes, IPN Incubadora, Ed C, Coimbra, Portugal.
Irina S MoreiraCNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.ORCID 0000-0003-2970-5250

Funding

COMPETE2030-FEDER-01475900 SI I&DT Individual MPr-2023-09Fundação para a Ciência e a Tecnologia 10.54499/UID/PRR/04539/2025Fundação para a Ciência e a Tecnologia 2022.12479.BDFundação para a Ciência e a Tecnologia 2024.03713.BDANAFundação para a Ciência e a Tecnologia 2024.07255.IACDCFundação para a Ciência e a Tecnologia LA/P/0058/2020
6 · The paper itself

Abstract

Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age-related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis. Despite these differences, converging evidence indicates that both conditions share molecular pathways and network-level dysfunction that emerge during brain ageing. Central to this convergence are G protein-coupled receptors (GPCRs), which act as integrative signalling hubs that regulate inflammation, metabolism, calcium (CA

Indexed as

Alzheimer DiseaseBrain NeoplasmsGlioblastomaReceptors, G-Protein-CoupledAnimalsHumansSignal TransductionReceptors, G-Protein-CoupledageingAlzheimer's diseasecellular senescenceglioblastoma multiformeG protein‐coupled receptorsNeuroinflammation

Identifiers

PMID41958080
PMCPMC13066513

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.