ArticleNMR in biomedicine2026
Heterogeneous Myocardial Adaptation to Pressure Overload Reveals a Spared, Vulnerable Segment Identified by Multiparametric Cardiac MRI.
Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cardiac adaptation to chronic pressure overload is traditionally viewed as a uniform concentric hypertrophy; however, growing evidence suggests that the myocardium responds in a spatially heterogeneous manner. This study aimed to systematically map regional and temporal adaptation patterns of the left ventricle (LV) under experimental pressure overload using high-resolution multiparametric cardiac MRI, with the hypothesis that distinct regional adaptation phenotypes contribute to both local functional differences and global ventricular dysfunction. Thirty-seven male 129/SvEv mice underwent transverse aortic constriction (TAC) surgery and were followed longitudinally over 7 weeks. Cine imaging, T1- and T2-mapping were performed at baseline, 3 days, 4 weeks and 7 weeks using a 9.4 T small-animal scanner. A 200-sector LV segmentation enabled quantitative regional analysis of wall thickness, fractional shortening (FS) and relaxation times. Global and regional imaging parameters were correlated with histological and biochemical indices at study termination, and statistical analyses were performed using the Mann-Whitney test and correlation modelling, with p < 0.05 considered significant. All TAC animals developed global LV hypertrophy and an early increase in LV mass (+62% ± 15% at Week 7, p < 0.001). Unexpectedly, in 18 animals (49%), a discrete basolateral LV segment failed to hypertrophy (spared hypertrophy, SH) despite uniform pressure elevation. This region exhibited markedly reduced regional FS (10.2% ± 3.1% vs. 24.9% ± 2.2%, p = 0.01) and was associated with lower global ejection fraction (32.5% ± 1.8% vs. 49.8% ± 4.1%, p < 0.05) and LV dilatation. Parametric MRI revealed distinct tissue signatures: T1 increased in hypertrophied sectors (+22.6% ± 1.1%), whereas it decreased in SH sectors (-5.1% ± 1.7%, p < 0.01) over the 7-week observation period. Sector-wise correlations linked T1 shortening with reduced FS (R
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