ReviewAsia Pacific allergy2026
Immunonutrition: Feeding the gut, skin, and immune system.
Review in Asia Pacific allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Early life is a critical period for the maturation of the gut microbiota, epithelial barriers, and immune system. Disruption of gut and skin barrier integrity during this window is increasingly recognized as a key mechanism contributing to the development of allergic diseases. Objective: This review summarizes evidence on how infant dietary patterns and macronutrients influence epithelial barriers, microbiota development, and immune programming for allergy prevention. Methods: A comprehensive search and analysis of current literature regarding macronutrients, including carbohydrates and fiber, proteins, and fats, dietary diversity, and Western-type dietary patterns, was conducted to explore their collective effects on epithelial barrier function, microbiota, and immune outcomes during pregnancy and early life. Particular attention was given to complementary feeding. Results: Dietary composition significantly influences epithelial barrier integrity and immune development through direct nutritional effects and microbiota-mediated pathways. Dietary fibers and human milk oligosaccharides promote short-chain fatty acid production and microbial diversity, strengthening epithelial junctions, mucus secretion, and regulatory immune responses. Adequate protein intake supports epithelial renewal, while microbial metabolism of amino acids such as tryptophan and branched-chain fatty acids enhances barrier integrity and immune homeostasis. Dietary fats critically shape epithelial lipid composition, with balanced omega-3 and omega-6 fatty acids supporting barrier resilience, whereas excess saturated and trans fats promote dysbiosis and inflammation. Furthermore, greater dietary diversity during pregnancy and infancy correlates with enhanced microbial maturation and reduced atopic risk. Conversely, Western-type diets rich in ultra-processed foods and additives disrupt epithelial barriers and promote pro-inflammatory immune programming with long-lasting consequences beyond infancy. Conclusions: Optimizing maternal and early life nutrition through breastfeeding support, timely and diverse complementary feeding, adequate intake of fiber, high-quality proteins and fats, and avoidance of Western-type dietary patterns represents a promising strategy to support gut and skin barrier and to reduce the risk of allergic diseases across the lifespan.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.