Evidence map›Paper›PMID 41958871›Full record

ArticleNPJ dementia2026

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology.

Szi Kay Leung, Emma M Walker, Stefania Policicchio, Aisha Dahir, Dorothea Seiler Vellame, Adam R Smith, Rhian Swarbrick, Katie Lunnon, Emma L Dempster, Zeshan Ahmed and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Szi Kay LeungDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Emma M WalkerDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Stefania PolicicchioDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Aisha DahirDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Dorothea Seiler VellameDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Adam R SmithDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Rhian SwarbrickDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Katie LunnonDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Emma L DempsterDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Zeshan AhmedEli Lilly, Seaport Innovation Centre, Boston, MA USA.
Eilis HannonDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Isabel Castanho *Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.
Jonathan Mill *Department of Clinical and Biomedical Sciences, University of Exeter, Exeter, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by progressive neurodegeneration driven by tau and amyloid-β (Aβ) pathology, although the underlying molecular mechanisms remain incompletely understood. Emerging evidence implicates altered DNA methylation (DNAm) in AD but comprehensive analyses in experimental models are limited. Here, we profile DNAm dynamics in two widely used transgenic mouse models of tau (rTg4510) and Aβ (J20) neuropathology, focusing on the entorhinal cortex and hippocampus. Using reduced representation bisulfite sequencing (RRBS) and methylation arrays across multiple disease stages, we identified widespread pathology-associated DNAm alterations in both models. Tau pathology in rTg4510 mice was associated with extensive DNAm remodeling at genes involved in neuronal plasticity, apoptosis, and lipid metabolism, including

Indexed as

DiseasesGeneticsMolecular biologyNeurologyNeuroscience

Identifiers

PMID41958871
PMCPMC13056554

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.