Evidence map›Paper›PMID 41958874›Full record

ArticleFrontiers in endocrinology2026

Epigenetic dichotomy in florid vs. gliotic proliferative diabetic retinopathy: hypomethylation of EGLN1 and MMP9 drives divergent pathogenic pathways in angiogenesis and fibrosis.

Xiaotong Ren, Lijin Cui, Yao Yao, Yuzhe Qiu, Chenyue Yu, Jian Guo

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaotong Ren *Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Lijin Cui *Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Yao Yao *Department of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Yuzhe QiuDepartment of Ophthalmology, Fujian Provincial Geriatric Hospital, Fuzhou, Fujian, China.
Chenyue YuDepartment of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Jian GuoDepartment of Ophthalmology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This exploratory, hypothesis-generating study aimed to investigate methylation differences in 16 angiogenesis- and fibrosis-related genes across diabetic retinopathy (DR) stages and proliferative diabetic retinopathy (PDR) subtypes (Florid and Gliotic), and to identify potential epigenetic biomarkers for disease progression. Methods: DNA methylation levels were analyzed in 38 diabetic patients stratified into three groups: Florid PDR (n=16), Gliotic PDR (n=13), and controls (no DR/non-proliferative DR, n=9). Targeted genes included Results: In the Florid PDR group, Conclusions: Distinct hypomethylation profiles in

Indexed as

Diabetic RetinopathyDNA MethylationEpigenesis, GeneticMatrix Metalloproteinase 9Neovascularization, PathologicAgedBiomarkersFemaleFibrosisHumansHypoxia-Inducible Factor-Proline DioxygenasesMaleMiddle AgedBiomarkersEGLN1 protein, humanHypoxia-Inducible Factor-Proline DioxygenasesMatrix Metalloproteinase 9MMP9 protein, humanEGLN1florid PDRgliotic PDRhypomethylationproliferative diabetic retinopathy (PDR)

Identifiers

PMID41958874
PMCPMC13056828

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.