ArticleFrontiers in endocrinology2026
Association of uric acid, calcium, and creatinine with bone mineral density in adults over 50: a cross-sectional study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: The relationship between uric acid (UA), calcium, creatinine, and bone mineral density (BMD) remains complex and potentially non-linear. Our objective was to explore these associations in individuals aged over 50 years, considering the interactive effects of body mass index (BMI) and renal function. Methods: Across-sectional study was conducted on 216 patients (aged ≥50 years). BMD was measured by dual-energy X-ray absorptiometry (DXA). Multivariate linear regression, generalized additive models (GAM), and stratified analyses were performed to evaluate the associations between metabolic parameters and BMD. Results: In multivariate regression, serum creatinine and age were significant predictors of BMD. GAM analyses revealed non-linear relationships: UA showed a positive association with BMD that plateaued at higher levels (>400 umol/L); BMI exhibited an inverted U-shaped association. Stratified analyses indicated that the positive UA-BMD association was significant only in individuals with normal BMI and lower creatinine levels. Feature importance analysis identified UA, BMI, and creatinine as the top predictors of BMD. Conclusions: In this population, UA, creatinine, and BMI exhibited complex interactive associations with BMD. These findings suggest that the protective effect of uric acid on bone may depend on metabolic status and renal function.
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