Evidence map›Paper›PMID 41958921›Full record

ArticleBrain communications2026

Accelerated brain ageing in migraine: a multilevel MRI-based brain-age modelling study.

Hung-Yu Liu, Chen-Yuan Kuo, Pei-Lin Lee, Yi-Hsuan Liu, Wei-Ta Chen, Shih-Pin Chen, Yen-Feng Wang, Ching-Po Lin, Kun-Hsien Chou, Shuu-Jiun Wang

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Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hung-Yu LiuDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Chen-Yuan KuoInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Pei-Lin LeeCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Yi-Hsuan LiuInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Wei-Ta ChenSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Shih-Pin ChenSchool of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.ORCID https://orcid.org/0000-0003-3492-9902
Yen-Feng WangDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Ching-Po LinInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.ORCID https://orcid.org/0000-0001-6848-8776
Kun-Hsien ChouInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Shuu-Jiun WangDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112201, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine is increasingly recognized as more than just an episodic headache disorder-it often carries a profound burden marked by emotional and cognitive disturbances. Recent insights point towards a possible link between migraine and accelerated brain ageing, yet the specific brain regions affected and the clinical implications remain poorly understood. We investigated grey matter-based brain age using voxel-based morphometry in 110 preventive treatment-naïve patients with migraine and 70 healthy controls, based on T1-weighted MRI and a validated brain-age prediction framework trained on data from 1318 healthy individuals. Compared with controls, patients with migraine exhibited a significantly higher global brain-age gap [mean difference = 4.24 years; confidence interval (CI, 0.12, 8.36);

Indexed as

brain agemigraineMRIspatial distribution

Identifiers

PMID41958921
PMCPMC13056717

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.