Evidence map›Paper›PMID 41959018›Full record

ArticlebioRxiv : the preprint server for biology2026

D2 autoreceptors gate vulnerability to cocaine use disorder.

Erin M Murray, Daniel Diaz-Urbina, Roland Bock, Emilya Ventriglia, Anna Tischer, Jung Hoon Shin, Seul Ah Lee, Lucy G Anderson, Sydney Cerveny, Isabel Bleimeister and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Erin M MurrayNIAAA, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-4179-7717
Daniel Diaz-UrbinaNIMH, National Institutes of Health, Bethesda, MD 20892.
Roland BockNIAAA, National Institutes of Health, Bethesda, MD 20892.
Emilya VentrigliaCenter on Compulsive Behaviors, National Institutes of Health, Bethesda, MD 208923.ORCID 0000-0001-5077-5443
Anna TischerNIDA, National Institutes of Health, Baltimore, MD 21224.ORCID 0009-0001-4268-5904
Jung Hoon ShinNIAAA, National Institutes of Health, Bethesda, MD 20892.
Seul Ah LeeNIMH, National Institutes of Health, Bethesda, MD 20892.
Lucy G AndersonNIMH, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-8908-2887
Sydney CervenyNIMH, National Institutes of Health, Bethesda, MD 20892.
Isabel BleimeisterNIAAA, National Institutes of Health, Bethesda, MD 20892.
Miriam E BocarslyNIAAA, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0001-9217-032X
Michael MichaelidesNIDA, National Institutes of Health, Baltimore, MD 21224.ORCID 0000-0003-0398-4917
Veronica A AlvarezNIAAA, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0003-2611-8675

Funding

Synaptic mechanisms underlying reward seeking and compulsive drug useZIAAA000421 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI ALVAREZ, VERONICA A · 2009 to 2025
$23.1M
Biobehavioral Imaging and Molecular Neuropsychopharmacology of Substance Abuse MechanismsZIADA000069 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI MICHAELIDES, MICHAEL · 2016 to 2025
$18.9M
Section on Neurobiology of Compulsive BehaviorsZIAMH002987 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ALVAREZ, VERONICA · 2023 to 2025
$5.2M
Intramural NIH HHS ZIA AA000421Intramural NIH HHS ZIA DA000069Intramural NIH HHS ZIA MH002987
6 · The paper itself

Abstract

A defining feature of substance use disorder is that repeated drug use does not always lead to addiction, motivating the search for biomarkers of vulnerability

Identifiers

PMID41959018
PMCPMC13060886

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.