Evidence map›Paper›PMID 41959270›Full record

ArticlebioRxiv : the preprint server for biology2026

Differential chromatin looping regulated by two GA-binding transcription factors creates an X-specific chromatin environment for dosage compensation.

Joseph Aguilera, Kaitlyn Cortez, Luna C Segarra Alonzo, Melissa Aldana, Angelica Aragon, Claire Gray, Morgan Woodman-Sousa, Kathryn J Grive, Mukulika Ray, Erica Larschan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph AguileraDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.ORCID 0000-0003-1824-361X
Kaitlyn CortezDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.
Luna C Segarra AlonzoDepartment of Biology, University of Puerto Rico, Río Piedras, San Juan, PR.ORCID 0009-0007-4309-8537
Melissa AldanaDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.
Angelica AragonDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.
Claire GrayDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.
Morgan Woodman-SousaDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.
Kathryn J GriveDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.ORCID 0000-0002-7102-817X
Mukulika RayDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.
Erica LarschanDepartment of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.

Funding

Coregulation of genes by pioneer transcription factors and noncoding RNAsR35GM153389 · NIGMS · BROWN UNIVERSITY · PI Erica Nicole Larschan · 2024 to 2026
$1.5M
NIGMS NIH HHS R35 GM153389
6 · The paper itself

Abstract

The mechanisms by which differential occupancy of transcription factors (TFs) at similar binding sites leads to context-specific targeting of large transcription complexes remain poorly understood. X chromosome upregulation (XCU), the most highly conserved step in dosage compensation and best studied in

Identifiers

PMID41959270
PMCPMC13061037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.