Evidence map›Paper›PMID 41959389›Full record

ArticlebioRxiv : the preprint server for biology2026

A highly dynamic active state for transducin-bound phosphodiesterase-6 in vertebrate phototransduction.

Jessica N Holechek, Julia Y Shang, Tufa E Assafa, Brian R Crane, Richard A Cerione

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica N HolechekDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-9449-1706
Julia Y ShangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Tufa E AssafaDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2352-685X
Brian R CraneDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-8234-9991
Richard A CerioneDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-4512-5897

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)R24GM146107 · NIGMS · CORNELL UNIVERSITY · PI BRIAN R CRANE, Jack H Freed · 2022 to 2026
$6.4M
Probing the molecular mechanisms that regulate key steps in the GPCR-sensory response pathway responsible for vision in dim lightR01EY034867 · NEI · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2023 to 2026
$1.5M
NEI NIH HHS R01 EY034867NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R24 GM146107
6 · The paper itself

Abstract

In vertebrate phototransduction, the G protein-coupled receptor rhodopsin activates the α-subunit of transducin (Gα

Identifiers

PMID41959389
PMCPMC13060319

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.