In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Johanne Marie JustesenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-0484-8522 Kimmie Vestergaard SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-3861-4484 Jayashri SeshadriNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Jens Skjoldan SvenningsenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-3529-8228 Matthew AguirreDepartment of Biomedical Data Science, Stanford University, Stanford, California, 94305, USA.ORCID 0000-0001-9069-6475 Yosuke TanigawaDepartment of Biomedical Data Science, Stanford University, Stanford, California, 94305, USA.ORCID 0000-0001-9759-157X Robert MinnekerDepartment of Biomedical Data Science, Stanford University, Stanford, California, 94305, USA.ORCID 0000-0002-8185-5937 Amalie Rasmussen LanngCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.ORCID 0000-0003-0199-8733 Cecilie Bæch-LaursenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-8526-1079 Emilie Skytte AndersenCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.ORCID 0000-0001-7466-9055 Louise J SkovNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-2977-9970 Sebastian B JørgensenExternal Exploration and Innovation Unit, Novo Nordisk A/S, 2760 Måløv, Denmark.ORCID 0000-0002-9648-0971 Ulrik BeckerGastrounit, Medical Division, Hvidovre Hospital, University of Copenhagen, 2650 Hvidovre, Denmark.ORCID 0000-0002-1678-7771 Filip Krag KnopCenter for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, 2900, Hellerup, Denmark.ORCID 0000-0002-2495-5034 Manuel RivasDepartment of Biomedical Data Science, Stanford University, Stanford, California, 94305, USA.ORCID 0000-0003-1457-9925 Niels Grarup *Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-5526-1070 Matthew Paul Gillum *Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0003-4893-012X Funding
Optimizing imputation for diverse populations in a distributed frameworkU01HG009080 · NHGRI · STANFORD UNIVERSITY · PI KENNY, EIMEAR ELIZABETH · 2016 to 2020
$5.2MNHGRI NIH HHS U01 HG009080
6 · The paper itselfAbstract
Alcohol is an ancient and enduring component of the human diet, yet it is a dose-dependent cytotoxin and teratogen, raising the possibility that endogenous, state-dependent mechanisms constrain intake. Growth differentiation factor 15 (GDF15) is an endocrine hormone that rises during pregnancy-predominantly via secretion from blastocyst-derived placental trophoblasts into the maternal circulation-and is also induced in other tissues, particularly hepatocytes, by toxins and cellular stress. However, its function in humans remains unclear. Here, we show that circulating GDF15 levels are elevated 5-fold in individuals with alcohol dependence, identify a rare loss-of-function variant in the GDF15 receptor gene GFRAL associated with approximately 2.6 additional UK alcohol units (~21 g ethanol) per week, and demonstrate that recombinant GDF15 reduces alcohol drinking in mice. Collectively, these findings support a model in which GDF15 acts as an endocrine signal induced by chronic alcohol exposure-and potentially during pregnancy-to limit alcohol intake in humans.
Indexed as
alcoholalcohol use disorderethanolgenetic association studyGFRALGrowth differentiation factor 15 (GDF15)UK Biobank
Identifiers
PMID41959486
PMCPMC13060954
What Socratic holds
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