Evidence map›Paper›PMID 41959518›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.

Leila Nabulsi, Melody J Y Kang, Neda Jahanshad, Genevieve McPhilemy, Fiona M Martyn, Bartholomeus Haarman, Colm McDonald, Brian Hallahan, Stefani O'Donoghue, Dan J Stein and 48 more

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Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

58 authors.

Leila NabulsiImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Melody J Y KangImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Genevieve McPhilemyClinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
Fiona M MartynClinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
Bartholomeus HaarmanDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Colm McDonaldClinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
Brian HallahanClinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
Stefani O'DonoghueClinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
Dan J SteinNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Fleur M HowellsDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Freda SchefflerNeuroscience Institute, University of Cape Town, Cape Town, South Africa.
Henk S TemminghDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
David C GlahnDepartment of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Amanda RodrigueDepartment of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Edith Pomarol-ClotetBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Eduard VietaBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Joaquim RaduaBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Raymond SalvadorBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Andriana KarukBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Erick J Canales-RodríguezBiomedical Research Networking Center for Mental Health Network (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Josselin HouenouINSERM U955, team "Translational Neuro-Psychiatry", Créteil, France.
Pauline FavreINSERM U955, team "Translational Neuro-Psychiatry", Créteil, France.
Mircea PolosanUniv. Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France.
Arnaud PouchonUniv. Grenoble Alpes, CHU Grenoble Alpes, Grenoble, France.
Paolo BrambillaDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Marcella BellaniSection of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Philip B MitchellDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Gloria RobertsDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tiana BorgersInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Kira FlinkenflügelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Jonathan ReppleInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Michèle WessaCentral Institut of Mental Health, Department of Neuropsychology and Psychological Resilience Research, Mannheim, Germany.
Mary L PhillipsDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lea TeutenbergPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Tilo KircherPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Benjamin StraubePhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Olaf SteinstraeterPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Frederike SteinPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Florian Thomas-OdenthalPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Nina AlexanderPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Paula L UsemannPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Andreas JansenPhilipps-Universität Marburg, Faculty of Medicine, Department of Psychiatry and Psychotherapy, Rudolf-Bultmann- Str. 8, Marburg, Germany.
Michael BerkOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.
Orwa DandashBrain & Mental Health Laboratory, School of Psychological Sciences & Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, VIC 3168, Australia.
Nadine ParkerCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Chao SuoTurner Institute for Brain and Mental Health, School of Psychological Science and Monash Biomedical Imaging, Monash University, Victoria, Australia.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Ole A AndreassenCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Christopher R K ChingImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, University of Southern California, Marina del Rey, CA, USA.
Dara M CannonClinical Neuroimaging Laboratory, Centre for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.
ENIGMA Bipolar Disorder Working Group

Funding

Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Gene Networks Influencing Psychotic Dysconnectivity in African AmericansR01MH106324 · NIMH · YALE UNIVERSITY · PI BLANGERO, JOHN, GLAHN, DAVID C · 2015 to 2019
$4.2M
ENIGMA Bipolar Initiative: A Global Study of Imaging Genomics & Clinical OutcomesR01MH129742 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christopher Ching, PAUL M THOMPSON · 2022 to 2026
$3.0M
Influence of Psychosis on Brain-Behavior Endophenotypes for Bipolar DisorderR01MH080912 · NIMH · YALE UNIVERSITY · PI GLAHN, DAVID C · 2008 to 2012
$2.6M
Global studies into the Genetic Architecture of the Brain's White Matter Network through Harmonized and Coordinated Analyses in the ENIGMA-ConsortiumR01MH134004 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Neda Jahanshad · 2023 to 2026
$2.6M
NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH080912NIMH NIH HHS R01 MH106324NIMH NIH HHS R01 MH129742NIMH NIH HHS R01 MH134004Wellcome Trust
6 · The paper itself

Abstract

Background: Large-scale T1-weighted MRI studies have established grey-matter abnormalities in bipolar disorder (BD), with our group contributing to consensus findings. However, structural connectivity, particularly within emotion- and reward-related circuits, remains poorly understood. Diffusion-weighted MRI (dMRI) enables investigation of white-matter pathways, yet prior work is constrained by small samples, methodological heterogeneity, and unclear medication effects. We conducted the largest dMRI network analysis in BD, relating symptom burden and polypharmacy to tractography-derived connectivity and graph-theoretic metrics. Methods: Cross-sectional structural and diffusion MRI scans from 449 individuals with BD (35.7±12.6 years) and 510 controls (33.3±12.6 years), aged 18-65, were analyzed across 16 ENIGMA-BD sites. Standardized segmentation/parcellation and constrained spherical deconvolution tractography generated individual structural connectivity matrices. Graph-theoretic metrics of global and subnetwork organization were related to symptom severity and medications. Results: BD showed widespread network alterations (lower density and efficiency, longer path length, and higher betweenness centrality), altered microstructural organization in a limbic-basal ganglia circuit, and abnormal streamline counts in a default-mode/salience/fronto-limbic-basal ganglia network. Longer illness duration, later onset, and psychosis history were associated with greater abnormalities in network architecture, whereas more manic episodes were associated with greater fronto-limbic connectivity. Antidepressant (particularly SSRI), anticonvulsant, and antipsychotic use related to poorer global and fronto-limbic connectivity; no clear lithium effects emerged. Conclusions: As the largest structural connectivity study in BD, we reveal widespread disruption in reward and emotion-regulation networks influenced by illness severity and medication use. Results show that multisite harmonization is feasible and highlight ENIGMA-BD as a scalable framework for identifying reproducible neurobiological markers.

Identifiers

PMID41959518
PMCPMC13060294

What Socratic holds

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LicenceCC BY-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.