Evidence map›Paper›PMID 41959520›Full record

ArticlebioRxiv : the preprint server for biology2026

The transcription factor Vca0578 (DsvR) mediated expression of ZapC is required to promote cell division during lytic transglycosylase insufficiency in

Upasana Basu, Anna Isabell Weaver, Nicole Lin, Asraa Ahmed, Sebastian Krautwurst, Kai Papenfort, Tobias Dörr

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Upasana BasuWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0002-9821-3594
Anna Isabell WeaverWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0002-0556-0336
Nicole LinWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0009-0009-5358-8876
Asraa AhmedWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.
Sebastian KrautwurstInstitute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University, Jena, Germany.
Kai PapenfortInstitute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University, Jena, Germany.
Tobias DörrWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States.ORCID 0000-0003-3283-9161

Funding

The mechanism of autolysin regulation in Vibrio choleraeR01GM130971 · NIGMS · CORNELL UNIVERSITY · PI DOERR, TOBIAS · 2019 to 2025
$2.0M
Understanding autolysin function in Gram-negative bacterial growth and morphogenesisR35GM161163 · NIGMS · CORNELL UNIVERSITY · PI Tobias Doerr · 2026 to 2026
$291k
NIGMS NIH HHS R01 GM130971NIGMS NIH HHS R35 GM161163
6 · The paper itself

Abstract

The bacterial peptidoglycan (PG) cell wall, a polymer made of amino-acid-bearing glycan strands, maintains cell shape, provides structural integrity, and protects against osmotic lysis. PG maintenance is an active process that requires regulated PG breakdown to make space for insertion of new PG strands. PG breakdown is accomplished by 'autolysins', i.e. endogenous enzymes with cell wall cleavage activity. The lytic transglycosylases (LTGs), a class of autolysins, for example, cleave glycan strands during PG remodelling. LTGs are broadly conserved and are highly redundant in bacteria, but their physiological role is poorly-defined. In this study, we interrogated physiological consequences of LTG insufficiency in

Indexed as

Cell divisionLytic transglycosylasePeptidoglycanZap proteinZ-ring

Identifiers

PMID41959520
PMCPMC13060122

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.