Evidence map›Paper›PMID 41959523›Full record

ArticlebioRxiv : the preprint server for biology2026

FNIP1 Modulates B Cell Receptor Signaling Strength by Coordinating Metabolism During Development.

Heon Park, Ryan Culbert, Dechen Sakya, Raynah R Silprasert, Brian M Iritani

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Heon ParkDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-6774-6515
Ryan CulbertDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Dechen SakyaDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Raynah R SilprasertDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Brian M IritaniDepartment of Comparative Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-1903-7850

Funding

WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunityR01AI158353 · NIAID · UNIVERSITY OF WASHINGTON · PI IRITANI, BRIAN M · 2021 to 2025
$2.8M
Dissecting Hem-1 functions in B lymphocyte Development and Primary Immunodeficiency DiseaseR21AI156243 · NIAID · UNIVERSITY OF WASHINGTON · PI IRITANI, BRIAN M · 2021 to 2022
$428k
Folliculin Interacting Proteins in Lymphocyte Development and AutoimmunityR21AI109020 · NIAID · UNIVERSITY OF WASHINGTON · PI IRITANI, BRIAN M · 2014 to 2015
$425k
NIAID NIH HHS R01 AI158353NIAID NIH HHS R21 AI109020NIAID NIH HHS R21 AI156243
6 · The paper itself

Abstract

B cell development relies on stringent checkpoints that ensure immune competence and eliminate autoreactive clones. Transitional B cells (B220

Indexed as

CD19Cell survivalNegative selectionPeripheral toleranceRagDTFEBTransitional B cells

Identifiers

PMID41959523
PMCPMC13060193

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.