Evidence map›Paper›PMID 41959534›Full record

ArticlebioRxiv : the preprint server for biology2026

Dissecting Complex Interactions Between Ferroptosis and the Proteasome.

Magdalena B Murray, Rishi Upadhyay, Krystina Szylo, Aastha Gautam, Judith Goncalves, Giovanni Forcina, Ananya Vinayak, Onn Brandmann, Scott J Dixon

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Magdalena B MurrayDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-6306-4568
Rishi UpadhyayDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Krystina SzyloDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Aastha GautamDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Judith GoncalvesDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Giovanni ForcinaDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Ananya VinayakDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Onn BrandmannDepartment of Biochemistry, Stanford University, Stanford, CA 94305, USA.
Scott J DixonDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6230-8199

Funding

Characterizing the Regulation of FerroptosisR01GM122923 · NIGMS · STANFORD UNIVERSITY · PI Scott Dixon · 2017 to 2026
$3.4M
Stress Response Pathways Regulating Protein HomeostasisR35GM153301 · NIGMS · STANFORD UNIVERSITY · PI Onn Brandman · 2024 to 2026
$1.4M
Investigating the regulation of cancer cell death by NFE2L1F31CA284784 · NCI · STANFORD UNIVERSITY · PI MURRAY, MAGDALENA · 2024 to 2025
$86k
NCI NIH HHS F31 CA284784NIGMS NIH HHS R01 GM122923NIGMS NIH HHS R35 GM153301
6 · The paper itself

Abstract

The proteasome is an essential multiprotein complex whose inhibition can lead to apoptosis. Ferroptosis is a non-apoptotic cell death mechanism whose fundamental regulation continues to be elucidated. How proteasome function regulates ferroptosis sensitivity is poorly understood and difficult to study given the essential nature of the proteasome. Here, we isolated the effects of proteasome inhibition on ferroptosis by combining direct cell death imaging, cell death pathway-specific inhibitors, and mathematical modeling. We find that proteasome inhibition enhances sensitivity to ferroptosis induced by glutathione peroxidase 4 (GPX4) inhibition while simultaneously promoting resistance to ferroptosis induced by system x

Indexed as

canceriron metabolismlipid peroxidationnecrosisOxidative stressprotein synthesisubiquitination

Identifiers

PMID41959534
PMCPMC13060147

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.