Evidence mapPaperPMID 41959546Full record

ArticleRSC advances2026

Incubation of brain organoids with fluorescent carbon nanodots.

Carla Sprengel, Ute Fischer, Arndt Borkhardt, Rainer Haas, Thomas Heinzel

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carla SprengelCondensed Matter Physics Laboratory, Heinrich-Heine-University Düsseldorf Germany Thomas.Heinzel@hhu.de.ORCID https://orcid.org/0009-0001-8959-1817
Ute FischerDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Düsseldorf Germany.
Arndt BorkhardtDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Düsseldorf Germany.
Rainer HaasDepartment of Haematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Düsseldorf Germany.
Thomas HeinzelCondensed Matter Physics Laboratory, Heinrich-Heine-University Düsseldorf Germany Thomas.Heinzel@hhu.de.ORCID https://orcid.org/0000-0001-5149-4379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain organoids are exposed during their growth to fluorescent carbon nanodots (CNDs). We observe that the CNDs penetrate through the whole organoid in all maturation stages and are taken up by viable cells irrespective of their type and location, most likely by endocytosis. They remain inside the cells after enzymatic dissociation of the organoids. No influence of the CNDs on the organoids' viability after 48 h exposure during the first 15 weeks could be detected. Our results suggest that CNDs are interesting candidates for multifunctional fluorescent labeling in organoid research and development, such as structural imaging or drug screening.

Identifiers

PMID41959546
PMCPMC13058803

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.