Evidence map›Paper›PMID 41959805›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Ionizing radiation acoustic beam localization: one step towards "proton surgery".

Wei Zhang, Ibrahim Oraiqat, Jiyeon Park, Glebys Gonzalez, Yiming Liu, Yaocai Huang, Sarah Dykstra, Lise Wei, Dale Litzenberg, Kyle Cuneo and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wei ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Ibrahim OraiqatDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida.
Jiyeon ParkDepartment of Radiation Oncology, University of Florida, Gainesville, Florida.
Glebys GonzalezDepartment of Machine Learning, Moffitt Cancer Center, Tampa, Florida.
Yiming LiuDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Yaocai HuangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Sarah DykstraDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Lise WeiDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Dale LitzenbergDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Kyle CuneoDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
William MendenhallDepartment of Radiation Oncology, University of Florida, Gainesville, Florida.
Curtis BryantDepartment of Radiation Oncology, University of Florida, Gainesville, Florida.
Samuel Jean-BaptisteDepartment of Radiation Oncology, University of Florida, Gainesville, Florida.
Perry JohnsonDepartment of Radiation Oncology, University of Florida, Gainesville, Florida.
Issam El NaqaDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida.
Xueding WangDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida.

Funding

Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapyR37CA222215 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EL NAQA, ISSAM M. · 2018 to 2024
$3.5M
An Ionizing Radiation Acoustics Imaging (iRAI) Approach for guided Flash RadiotherapyR01CA266803 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BORTFELD, THOMAS R., EL NAQA, ISSAM M. · 2022 to 2025
$3.3M
NCI NIH HHS R01 CA266803NCI NIH HHS R37 CA222215
6 · The paper itself

Abstract

Proton beam therapy (PBT) offers a unique potential for dose conformity to tumors while sparing surrounding healthy tissues. Current PBT accuracy, however, is fundamentally limited by range uncertainties from tissue density variations and anatomical changes, yet no clinically viable methods exist for localizing the dose delivery pulse-by-pulse inside patients during pencil beam scanning (PBS). We developed and clinically demonstrated a first-of-its-kind radiation acoustic beam localization (iRABL) system for real-time tracking PBS trajectory and mapping dose deposition deep in patient's body during PBT. A clinical-grade compact iRABL system featuring high speed, super-resolution, and high sensitivity was specifically designed for PBT applications. Its clinical feasibility was validated through the first-in-human study on prostate cancer patients, demonstrating the capability for

Identifiers

PMID41959805
PMCPMC13060993

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.