ArticleJTCVS open2026
Impact of leaflet stiffness in aortic valve neocuspidization in ex vivo biomechanical simulation.
Article in JTCVS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Objective: This study aimed to analyze how varying glutaraldehyde fixation of porcine pericardium impacts the biomechanics of aortic valve neocuspidization (ie, Ozaki procedure). Methods: Four bovine aortic roots were mounted in a 3-dimensional printed left heart simulator. Leaflets were tanned for 2, 6, and 10 minutes in 0.625% glutaraldehyde and used to create the Ozaki models in the same aortic root. Three models were biomechanically compared with a native aortic control valve. Hemodynamics, high-speed videography, and echocardiography data were collected. The flexibility and strength of each pericardium were tested using tensile strength. Results: Tensile stress and strain were best at 10-minute tanning. As neo-leaflet tanning duration increased from 2 to 10 minutes, the transvalvular pressure gradient decreased by 38.0% (13.7 ± 4.0 mm Hg vs 8.5 ± 4.8 mm Hg, Conclusions: Porcine pericardium tanned in glutaraldehyde for 10 minutes resulted in the lowest valve regurgitation, lowest pressure gradient, and highest leaflet velocities in ex vivo simulation. These observations can be used to optimize valve function and enhance aortic valve reconstruction techniques.
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