SynthesisFrontiers in genetics2026
Genetic aetiology of global developmental delay and intellectual disability in Africa: a scoping review.
Synthesis in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Melatonin as a protector against endocrine disruption across tissues: A systematic review.Physiological reports · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The genetic aetiology of global developmental delay (GDD) and intellectual disability (ID) in Africa is poorly understood. This review synthesises the available information on this topic. Methods: Original articles published in the English language between January 2000 and June 2024 on the African population were included. Literature was retrieved from PubMed, Scopus, and Web of Science, in accordance with the PRISMA guidelines. Results: Of all the 54 African countries, only 13 reported the genetic factors associated with GDD and ID. The genes related to GDD and ID were reported in Egypt (22), Tunisia (17), Morocco (16), South Africa (10), Algeria (4), Sudan (3), Libya (2), Nigeria (2), Rwanda (4), Mali (1), Cameroon (1), DRC (2), and Tanzania (1), although some genes were reported in more than one African country. At least 45 genes associated with GDD and ID have been reported in the African population, whereas 21 genes associated with these disorders are yet to be documented in Africa. Conclusion: This review provides, to the best of our knowledge, the first comprehensive review of the genetic aetiology of GDD and ID in Africa. It presents an imbalance of gene research on GDD and ID across African regions, with North African countries dominating this field of study.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.