ArticleFrontiers in psychiatry2026
Analysis of complete blood counts and derived inflammatory indices with non-suicidal self-injury and suicide attempt in adolescents with major depressive disorder.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Non-suicidal self-injury (NSSI) and suicide attempt (SA) are highly comorbid in adolescents with major depressive disorder (MDD), yet their distinct biological correlates are unclear. This study investigated the potential of complete blood count (CBC) parameters and derived inflammatory markers to differentiate clinical subtypes of adolescent MDD with NSSI and/or SA. Methods: A retrospective cross-sectional study was conducted involving 618 adolescent inpatients with MDD. The participants were categorized into four clinical subgroups: pure MDD group (without NSSI and SA, n=382), NSSI-only group (n=131), SA-only group (n=41), and NSSI+SA comorbid group (n=64). CBC parameters and derived inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), were compared across groups. Statistical analyses included Kruskal-Wallis H tests with Results: The NSSI+SA comorbid group exhibited a robust inflammatory signature, with significantly elevated neutrophils, NLR, MLR, PLR, and SII, alongside reduced lymphocytes, compared to all the other subgroups (all Conclusion: NSSI and SA behaviors in adolescents with MDD are associated with distinct inflammatory biological bases. NSSI+SA comorbidity is linked to robust activation of the innate immune response, with elevated levels of NLR, MLR, PLR, and SII serving as potential auxiliary biomarkers for its identification.
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