Evidence map›Paper›PMID 41960422›Full record

ArticleFrontiers in molecular neuroscience2026

Chronic pain, fatigue, and emotional distress in female

Dragana Protic, Maja Stojkovic, Randi Hagerman, Danijela Bascarevic, Jovana Ogrizovic, Sanja Dimitrijevic, Jovan Pesovic, Dusanka Savic-Pavicevic, Dejan Budimirovic

Abstract read
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In one paragraph

Article in Frontiers in molecular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dragana ProticDepartment of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Maja StojkovicDepartment of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Randi HagermanDepartment of Pediatrics, University of California Davis School of Medicine, Sacramento, CA, United States.
Danijela BascarevicSpecial Hospital for Cerebral Palsy and Developmental Neurology, Belgrade, Serbia.
Jovana OgrizovicSpecial Hospital for Cerebral Palsy and Developmental Neurology, Belgrade, Serbia.
Sanja DimitrijevicInstitute for Rehabilitation, Belgrade, Serbia.
Jovan PesovicCenter for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Dusanka Savic-PavicevicCenter for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Dejan BudimirovicDivision of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Carriers of the Methods: The study was conducted at the Belgrade Fragile X Clinic on a clinical sample of 35 women with the PM and 35 controls using an adapted version of the Symptom Impact Questionnaire and the Fatigue Assessment Scale. The survey was designed to collect data on FXAND symptoms, including chronic pain, fatigue, anxiety, and depressive symptoms. Each symptom was self-rated by participants on a scale from 0 to 10. Data were analyzed using appropriate statistical methods. Results: Women with the PM (mean age: 44.51 ± 12.90 y.; 90.51 ± 22.04 CGG repeats) had statistically significant higher frequency and severity of chronic pain ( Conclusion: Female PM carriers experience significantly higher frequency and severity of FXAND-related symptoms. Our findings of an association between fatigue, anxiety, and depressive symptoms highlight the need for comprehensive screening and underscore the importance of recognizing and treating individuals with FXAND.

Indexed as

anxietychronic fatiguechronic paindepressionfatigue assessment scaleFMR1 gene premutationild care foundation (www.ildcare.nl)symptom impact questionnaire

Identifiers

PMID41960422
PMCPMC13057454

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.