Evidence map›Paper›PMID 41960638›Full record

ArticleRedox report : communications in free radical research2026

Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.

Wenlong Lin, Caitao Dong, Qinhong Jiang, Yuanquan Lou, Long Wang, Ziqi He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenlong LinDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Caitao DongDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Qinhong JiangDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Yuanquan LouDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Long WangDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Ziqi HeDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the role of the SIRT5-PRDX6 axis during the pathogenesis of sepsis-associated acute kidney injury (SA-AKI).

methods

resultsFerroptosis was critical in SA-AKI progression. In LPS-induced HK-2 cells, HMOX1, NQO-1, ACSL4, Fe²⁺, IL-1β, TNF-

conclusionThe SIRT5-PRDX6 axis regulates SA-AKI pathogenesis by modulating ferroptosis and represents a novel potential therapeutic target.

Indexed as

Acute Kidney InjuryFerroptosisPeroxiredoxin VISepsisSirtuinsAnimalsCell LineHumansMaleMiceMice, Inbred C57BLOxidative StressPeroxiredoxin VISIRT5 protein, mouseSirtuinsdesuccinylationferroptosisLipid peroxidationpost-translational modificationPRDX6Sepsis-associated acute kidney injurySIRT5succinylation

Identifiers

PMID41960638
PMCPMC13072693

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.