Evidence map›Paper›PMID 41960855›Full record

ArticleMolecular microbiology2026

An Escherichia coli Phosphotransferase System Modulates Methylglyoxal Resistance by Regulating Intracellular Potassium.

Sara Alexander, Mark Goulian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sara AlexanderCell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mark GoulianDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
Phosphorelay signaling and regulation in bacteriaR35GM139541 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2021 to 2025
$2.0M
The Role of Post-Translational Modifications in Bacterial Responses to MethylglyoxalF31GM154412 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ALEXANDER, SARA · 2024 to 2025
$99k
NIGMS NIH HHS F31 GM154412NIGMS NIH HHS F31GM154412NIGMS NIH HHS R35 GM139541NIGMS NIH HHS R35GM139541NIGMS NIH HHS T32 GM007229NIGMS NIH HHS T32 GM07229
6 · The paper itself

Abstract

Methylglyoxal is a toxic aldehyde produced during cellular metabolism across all domains of life. To cope with methylglyoxal stress, Escherichia coli employs the glyoxalase detoxification pathway coupled with Kef-mediated potassium/proton antiport. However, the Kef system is protective only when extracellular potassium is well below concentrations typically found in mammalian hosts. The regulatory phosphotransferase system (PTS) that is historically known as the nitrogen-related PTS (PTS

Indexed as

Escherichia coliPhosphoenolpyruvate Sugar Phosphotransferase SystemPotassiumPotassium-Hydrogen AntiportersPyruvaldehydeEscherichia coli ProteinsStress, PhysiologicalEscherichia coli ProteinsPhosphoenolpyruvate Sugar Phosphotransferase SystemPotassiumPotassium-Hydrogen AntiportersPyruvaldehydeEscherichia colimethylglyoxalpHphosphotransferase systemspotassiumPTSNtrpyruvaldehyde

Identifiers

PMID41960855
PMCPMC13445646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.