Evidence map›Paper›PMID 41961315›Full record

ArticleAbdominal radiology (New York)2026

Intraindividual comparison of 3-T and 5-T gadoxetic acid-enhanced MRI for evaluating HCC: initial findings.

Shaopeng Li, Shuhang Liang, Mengqiu Liu, Xudan Chen, Dawei Yin, Zhichao Feng, Runyu Tang, Xiaopeng Song, Peng Wang, Ying Liu and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shaopeng LiDepartment of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Shuhang LiangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, China.
Mengqiu LiuDepartment of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xudan ChenDepartment of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Dawei YinDepartment of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Zhichao FengCentral Research Institute, United Imaging Healthcare, Shanghai, China.
Runyu TangCentral Research Institute, United Imaging Healthcare, Shanghai, China.
Xiaopeng SongCentral Research Institute, United Imaging Healthcare, Shanghai, China.
Peng WangDepartment of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Ying LiuDepartment of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Lianxin LiuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, China. liulx@ustc.edu.cn.

Funding

National Key RandD Program of China 2019YFA0709300
6 · The paper itself

Abstract

backgroundWe aimed to evaluate the utility of 5-T Gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) by intraindividual comparison with 3-T MRI, with a focus on the image quality and diagnosis of hepatocellular carcinoma (HCC).

methodsWe prospectively enrolled 41 patients with suspected HCC who underwent dynamic Gd-EOB-DTPA-enhanced MRI using both 5-T and 3-T scanners. Artificial intelligence-assisted compressed sensing (ACS) and parallel imaging (PI) were both used for hepatobiliary phase (HBP) imaging at 5-T. Two radiologists performed qualitative and quantitative assessments of image quality and evaluations of imaging features. Wilcoxon signed-rank, paired χ

resultsAll subjective image quality scores ranged from good to excellent. The subjective scores of contrast-enhanced phases for 5-T images were higher than those for 3-T images (all p < 0.05), except for image artifacts. For diffusion-weighted imaging (DWI), the subjective scores of the clarity of the lesion margins on 5-T images were higher than those on 3-T images (p = 0.021). Quantitative measures were also greater for 5-T images (all p < 0.05). For DWI, the contrast ratio (CR) at 5-T was greater (p < 0.05). Subjective and quantitative assessments of HBP imaging were higher with ACS (all p < 0.05). The detection rate of enhancing capsule was greater for 5-T images (p = 0.016), as was the rate of peritumoral hypointensity on the HBP images at 5-T using ACS (p = 0.015).

conclusionsCompared with 3-T MRI, liver dynamic Gd-EOB-DTPA-enhanced 5-T MRI demonstrated superior image quality for contrast-enhanced phases and greater sensitivity in detecting enhancing capsule in HCC. The integration of 5-T MRI and ACS technology has the potential to further improve image quality and the assessment of imaging features. RELEVANCE STATEMENT: Gd-EOB-DTPA-enhanced 5-T MRI provides promising potential for accurate HCC evaluation.

Indexed as

Carcinoma, HepatocellularContrast MediaGadolinium DTPAImage EnhancementLiver NeoplasmsMagnetic Resonance ImagingAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAArtificial intelligenceGadolinium ethoxybenzyl DTPAHepatocellular carcinomaLiver neoplasmsMagnetic resonance imaging

Identifiers

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.