Evidence map›Paper›PMID 41961385›Full record

ArticleEuropean radiology experimental2026

Inflammatory and resolution stages of hepatic injury: imaging with USPIO-enhanced MRI in mice.

Joao Piraquive Agudelo, Sabrina Doblas, Katell Peoc'h, Bich-Thuy Doan, Philippe Garteiser, Bernard E Van Beers

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In one paragraph

Article in European radiology experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joao Piraquive AgudeloLaboratory of Imaging Biomarkers, Center for Research on Inflammation, Inserm U1149, Université Paris Cité, Paris, France.
Sabrina DoblasLaboratory of Imaging Biomarkers, Center for Research on Inflammation, Inserm U1149, Université Paris Cité, Paris, France.
Katell Peoc'hDepartment of Biochemistry and Nutrition, Beaujon University Hospital Paris Nord, AP-HP, France and UMR 1149 Inserm, Paris, France.
Bich-Thuy DoanUnité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Cité, UMR 8258 CNRS, Paris, France.
Philippe GarteiserLaboratory of Imaging Biomarkers, Center for Research on Inflammation, Inserm U1149, Université Paris Cité, Paris, France. philippe.garteiser@inserm.fr.ORCID http://orcid.org/0000-0003-0157-8851
Bernard E Van BeersLaboratory of Imaging Biomarkers, Center for Research on Inflammation, Inserm U1149, Université Paris Cité, Paris, France.

Funding

France Life Imaging ANR-11-INBS-0006Université Paris Cité Imageries du Vivant
6 · The paper itself

Abstract

objectiveLiver injury includes inflammation and resolution stages with different macrophage populations. Hepatic macrophages can be imaged with ultrasmall paramagnetic iron oxide (USPIO) nanoparticles-enhanced magnetic resonance imaging (MRI). We aimed to assess if inflammation and resolution stages of liver injury could be differentiated with USPIO-enhanced MRI in mice. MATERIALS AND

methodsThree groups of C57BL/6JRj mice (control, inflammation, resolution; n = 10 for each group) were imaged. Liver fibrosis was induced by intraperitoneal carbon tetrachloride injections for 6 weeks. Multigradient-echo MRI was performed before, 24, and 48 h after intravenous injection of fluorescent USPIO. Contrast uptake was quantified with

results

conclusionOur results suggest that the inflammatory and resolution stages of hepatic injury can be assessed with USPIO-enhanced MRI. RELEVANCE STATEMENT: Our study demonstrates that USPIO-enhanced MRI can be used to monitor the inflammatory and resolution phases of hepatic injury in mice. If future studies confirm these findings, this imaging method might be valuable for tracking hepatic inflammation dynamics. KEY POINTS: Liver

Indexed as

DextransInflammationLiverLiver CirrhosisMagnetic Resonance ImagingMagnetite NanoparticlesAnimalsContrast MediaMacrophagesMaleMiceMice, Inbred C57BLContrast MediaDextransferumoxtran-10Magnetite NanoparticlesInflammationLiverMacrophagesMagnetic iron oxide nanoparticlesMagnetic resonance imaging

Identifiers

PMID41961385
PMCPMC13069072

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.