Evidence map›Paper›PMID 41961389›Full record

ArticleMolecular diversity2026

Network pharmacology, molecular docking, and In Vitro evaluation of morin against gastric cancer.

Nilesh Naskar, Sunil Kumar, Deepanshu Mamgai, Harish Chandra Vishwakarma, Santosh Kumar Guru, Bijo Mathew, Naseer Maliyakkal, Uday R Kumar, Shweta Shrivastava, Manish Kumar Jeengar

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nilesh NaskarDepartment of Pharmacology, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India.
Sunil Kumar *Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India.
Deepanshu Mamgai *Department of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Harish Chandra VishwakarmaDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India.
Santosh Kumar GuruDepartment of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India.ORCID http://orcid.org/0000-0002-6658-4497
Naseer MaliyakkalDepartment of Anesthesia and Operations, College of Applied Medical Sciences, King Khalid University, Khamis Mushait, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0001-6682-3876
Uday R KumarDepartment of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Shweta ShrivastavaSchool of Pharmacy, School of Health and Allied Sciences, ARKA JAIN University, Gamharia, Seraikela Kharsawan, Jharkhand, 832108, India.
Manish Kumar JeengarDepartment of Pharmacology, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India. manishkumarj@pharmacy.aims.amrita.edu.ORCID http://orcid.org/0000-0001-6035-8643

Funding

Amrita Vishwa Vidyapeetham University University Seed GrantThe Deanship of Research and Graduate Studies at King Khalid University RGP1/149/46
6 · The paper itself

Abstract

Gastric cancer (GC) remains one of the most prevalent and lethal malignancies worldwide. Natural flavonoids are increasingly recognized for their therapeutic potential due to their multi-target actions and favourable safety profiles. Morin, a dietary flavonol found in several plants of the Rosaceae, Moraceae, and Fagaceae families, has not been well explored in GC. In this study, network pharmacology analysis identified ten major morin-associated hub genes (PIK3R3, PIK3CA, PIK3CB, PIK3CD, PIK3R2, PLCG1, JAK2, IGF1R, ZAP70, and ERBB4), several of which are key regulators of the PI3K-Akt signalling axis. Molecular docking showed strong binding affinities of morin toward PIK3CD (-11.01 kcal/mol), ZAP70 (-10.72 kcal/mol), JAK2 (-10.53 kcal/mol), IGF1R (-9.99 kcal/mol), PIK3CA (-9.79 kcal/mol), and ERBB4 (-8.83 kcal/mol). Molecular dynamics simulations of 500 ns, along with PCA, DCCM, FEL, and MM-GBSA analyses further confirmed stable interaction of morin with PIK3CA. In vitro, morin demonstrated selective cytotoxicity, with low IC

Indexed as

Antineoplastic AgentsFlavonoidsMolecular Docking SimulationNetwork PharmacologyStomach NeoplasmsCell Line, TumorCell ProliferationFlavonesHumansMolecular Dynamics SimulationSignal TransductionAntineoplastic AgentsFlavonesFlavonoidsmorinAGS cellsGastric cancerMolecular dockingMolecular dynamicsMorinNetwork pharmacology

Identifiers

PMID41961389

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.