ArticleMedicine2026
Statin use and risk of periodontitis in US adults: A population-based cross-sectional study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a chronic inflammatory disease and a leading cause of tooth loss among adults. Beyond their lipid-lowering effects, statins exhibit anti-inflammatory and bone-regenerative properties that may influence periodontal health; however, the existing evidence remains inconsistent. This study aimed to examine the association between statin use and periodontitis in a nationally representative US cohort. Data were obtained from 10,714 adults aged ≥30 years who participated in the 2009 to 2014 National Health and Nutrition Examination Survey. Statin use and duration were determined from prescription medication records, and periodontitis was defined according to the Centers for Disease Control and Prevention and the American Academy of Periodontology criteria. Weighted logistic regression models were applied to assess the association between statin use and periodontitis while adjusting for demographic, socioeconomic, lifestyle, and metabolic factors. Subgroup analyses were performed based on statin type and duration of use. After the application of survey weights, the findings were representative of 144.1 million US adults, with an overall periodontitis prevalence of 37.96%. In the fully adjusted model, statin use was significantly associated with a reduced risk of periodontitis (adjusted odds ratio [OR] = 0.83, 95% confidence interval [CI]: 0.69-0.98, P = .038). This inverse association was more pronounced among overweight individuals (OR = 0.73, 95% CI: 0.56-0.95, P = .031), long-term statin users (>5 years; OR = 0.77, 95% CI: 0.61-0.98, P = .039), and users of atorvastatin (OR = 0.68, 95% CI: 0.48-0.97, P = .037). Statin use was independently associated with a lower risk of periodontitis among US adults. This protective association was particularly evident in long-term users and individuals taking atorvastatin, supporting the hypothesis that the pleiotropic anti-inflammatory effects of statins may provide periodontal benefits. These findings suggest a potential role for statins in host-modulation therapy; however, prospective studies are required to establish causality.
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