Evidence map›Paper›PMID 41961883›Full record

ArticleArchiv der Pharmazie2026

Synthesis and Characterization of Sulfonamide-Schiff Bases, and Investigation of Cytotoxic, Antioxidant, HDAC, and Apoptotic Activities in Human Colon Cancer Cells (DLD-1 and HT-29).

Seda Mesci, Berna Kocaman, Aliye Gediz Erturk, Emine Bagdatli, Burak Yazgan, Tuba Yildirim

Abstract read
In one paragraph

Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seda MesciProject Coordination and Guidance Office, Rectorate, Hitit University, Çorum, Turkey.ORCID https://orcid.org/0000-0002-5440-302X
Berna KocamanDepartment of Biotechnology, Institute of Science, Amasya University, Amasya, Turkey.ORCID https://orcid.org/0000-0002-5578-8697
Aliye Gediz ErturkDepartment of Chemistry, Faculty of Science and Arts, Ordu University, Ordu, Turkey.ORCID https://orcid.org/0000-0003-0831-7056
Emine BagdatliDepartment of Chemistry, Faculty of Science and Arts, Ordu University, Ordu, Turkey.ORCID https://orcid.org/0000-0001-5946-2988
Burak YazganDepartment of Medical Services and Techniques, Sabuncuoğlu Serefeddin Health Services Vocational School, Amasya University, Amasya, Turkey.ORCID https://orcid.org/0000-0003-0717-7768
Tuba YildirimDepartment of Biology, Faculty of Art and Science, Amasya University, Amasya, Turkey.ORCID https://orcid.org/0000-0001-8575-4802

Funding

Amasya Üniversitesi FMB-BAP 20-0456Hitit Üniversitesi HÜBTUAM19001.21.001
6 · The paper itself

Abstract

Comprehending the intricate mechanisms of apoptosis and its interaction with cytotoxic, antioxidant, and HDAC activities is imperative for devising effective cancer therapies. Sulfonamides and Schiff bases are compounds of pharmacological importance with known anticancer activity. Our study aimed to investigate the cytotoxic, antioxidant, HDAC, and apoptotic activities of new sulfonamide-Schiff bases in human colon cancer cells (DLD-1 and HT-29). New sulfonamide-derived Schiff base compounds (3a-d) were synthesized from the condensation of sulfamethoxypyridazine (1) and various aromatic aldehydes, and were characterized by FTIR, NMR (

Indexed as

Antineoplastic AgentsAntioxidantsApoptosisColonic NeoplasmsHistone Deacetylase InhibitorsSulfonamidesCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHistone DeacetylasesHT29 CellsHumansMolecular StructureSchiff BasesStructure-Activity RelationshipAntineoplastic AgentsAntioxidantsHistone Deacetylase InhibitorsHistone DeacetylasesSchiff BasesSulfonamidesantioxidantapoptoticcolon cancercytotoxicHDACSchiff basesulfonamide

Identifiers

PMID41961883
PMCPMC13068298

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.