ArticleThe Journal of international medical research2026
Association between cardiometabolic index and high-sensitivity C-reactive protein: A cross-sectional study from National Health and Nutrition Examination Survey 2015 to 2018.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveHigh-sensitivity C-reactive protein, a key inflammatory biomarker, can indicate the risk of cardiovascular diseases. The cardiometabolic index has been associated with metabolic and cardiovascular outcomes; however, its direct relationship with high-sensitivity C-reactive protein remains unclear. This study aimed to explore this association and identify influencing factors in adult population.MethodsThis retrospective cross-sectional study used data from the 2015-2018 National Health and Nutrition Examination Survey. A multivariate logistic regression model was applied to assess the association between cardiometabolic index and high-sensitivity C-reactive protein levels (>3.0 mg/L) in 3970 adults, with adjustment for demographic characteristics, comorbidities, and lifestyle factors.ResultsCardiometabolic index was independently associated with high-risk high-sensitivity C-reactive protein (adjusted odds ratio = 1.11, 95% confidence interval: 1.03-1.19, p = 0.007). Subgroup analyses indicated that the association was more pronounced in females and non-Hispanic Black participants (p values for interaction were <0.001 and 0.004, respectively). Restricted cubic spline curves confirmed a nonlinear relationship between cardiometabolic index and high-risk high-sensitivity C-reactive protein (nonlinearity p < 0.001).ConclusionCardiometabolic index demonstrated a significant positive association with high-risk high-sensitivity C-reactive protein in US adults, serving as a marker linking cardiometabolic status to chronic inflammation. Further studies are needed to validate causality and explore cardiometabolic index-guided prevention.
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