ReviewTranslational psychiatry2026
Cognitive trajectories in Parkinson's disease patients, a review on the impact of subthalamic deep brain stimulation (STN-DBS) and emerging adaptive strategies.
Review in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- What's in a name? reframing advanced Parkinson's disease as a multidimensional state.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While deep brain stimulation (DBS) is well-established for managing motor symptoms in Parkinson's disease (PD) and improving patient's quality of life, its impact on cognition is still not properly addressed. Cognitive impairment in PD often affects verbal fluency, attention, and executive functions, and may interact with disease progression, dopaminergic medication, and stimulation parameters. These outcomes are shaped not only by the stimulation itself but also by factors such as baseline cognitive status, lead location, disease heterogeneity, and parameter selection. The emerging development of closed-loop DBS (CL-DBS) offers a promising tailored neuromodulation strategy that may help reduce DBS side effects while enhancing non-motor function. Given the extensive yet heterogeneous literature on cognitive outcomes after STN-DBS, this review integrates mechanistic insights from human and animal studies to clarify how stimulation parameters, anatomical targeting, and network-level dynamics influence postoperative cognitive trajectories. We summarize established cognitive effects of conventional DBS, emphasize sources of interindividual variability, and evaluate how adaptive stimulation paradigms may modulate cognitive and decision-making processes. Finally, we outline translational considerations for biomarker development and personalized neuromodulation strategies aimed at preserving cognition while maintaining motor benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.